Phospholipase C β3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice
Wang Z, Liu B, Wang P, Dong X, Fernandez-Hernando C, Li Z, Hla T, Li Z, Claffey K, Smith JD, Wu D. Phospholipase C β3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. Journal Of Clinical Investigation 2007, 118: 195-204. PMID: 18079968, PMCID: PMC2129238, DOI: 10.1172/jci33139.Peer-Reviewed Original ResearchConceptsPLC-beta3PLC-betaPKC-dependent upregulationMacrophage survivalPLC isoformsNovel roleBcl-xLMultiple inducersSubsequent differentiationApoptotic inductionAtherosclerotic plaquesMacrophage apoptosisApoE-deficient mouse modelPLC activityPLC-beta2Murine macrophagesAtherosclerotic lesion sizeReduction of atherosclerosisPotential targetLipid-laden macrophagesTreatment of atherosclerosisBeta3Key membersMacrophage functionApoptosis