2024
Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis
Wang Y, Wang H, Ma X, Zhu Z, Tian X, Fu R, Jia L. Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis. BMC Nephrology 2024, 25: 35. PMID: 38273279, PMCID: PMC10811929, DOI: 10.1186/s12882-024-03465-6.Peer-Reviewed Original ResearchConceptsIgAN patientsFibrinogen degradation productsIgA nephropathyIgAVN patientsLevels of plasma D-dimerLevels of serum creatininePartial remission rateSevere coagulation abnormalitiesPlasma D-dimerPoor renal functionChronic kidney injuryRemission ratePathological resultsSerum creatinineAbdominal symptomsRenal functionCoagulation abnormalitiesDeposition of fibrinogenKidney biopsyD-dimerKidney injuryCoagulation functionIgAVNIgAN groupMethodsA total
2023
Understanding Nephrotic Syndrome Using Kidney Transcriptome Profiling and Computational Studies
Rangel P, Tian X. Understanding Nephrotic Syndrome Using Kidney Transcriptome Profiling and Computational Studies. Kidney360 2023, 4: e431-e433. PMID: 37103957, PMCID: PMC10371383, DOI: 10.34067/kid.0000000000000117.Commentaries, Editorials and Letters
2020
Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes
La TM, Tachibana H, Li S, Abe T, Seiriki S, Nagaoka H, Takashima E, Takeda T, Ogawa D, Makino S, Asanuma K, Watanabe M, Tian X, Ishibe S, Sakane A, Sasaki T, Wada J, Takei K, Yamada H. Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes. The FASEB Journal 2020, 34: 16449-16463. PMID: 33070431, DOI: 10.1096/fj.202001240rr.Peer-Reviewed Original ResearchConceptsDynamin 1Microtubule organizationMouse podocytesΑ-tubulinMicrotubule bundlesGlomerular podocytesEndocytic proteinsMicrotubule bundle formationStabilization of microtubulesAcetylated α-tubulinVesicle formationNocodazole resistanceImmunoelectron microscopyMicrotubulesPhysiological significanceBundle formationRat podocytes
2010
Acid regulation of NaDC-1 requires a functional endothelin B receptor
Liu L, Zacchia M, Tian X, Wan L, Sakamoto A, Yanagisawa M, Alpern RJ, Preisig PA. Acid regulation of NaDC-1 requires a functional endothelin B receptor. Kidney International 2010, 78: 895-904. PMID: 20703215, DOI: 10.1038/ki.2010.264.Peer-Reviewed Original ResearchMeSH KeywordsAcidosisAnimalsBiological TransportCell LineDicarboxylic Acid TransportersDisease Models, AnimalEndothelin B Receptor AntagonistsEndothelin-1Hydrogen-Ion ConcentrationKidneyMiceMice, KnockoutMicrovilliOligopeptidesOpossumsOrganic Anion Transporters, Sodium-DependentPiperidinesProtein Structure, TertiaryReceptor, Endothelin AReceptor, Endothelin BRecombinant Fusion ProteinsSignal TransductionSymportersTime FactorsTransfectionConceptsEndothelin-1Endothelin-B receptor antagonistFunctional endothelin B receptorsStimulatory effectAcid-stimulatory effectET-1 effectsB receptor antagonistNHE3 activityEndothelin B receptorWild-type miceET-1 stimulationMajor physiological stimulusNaDC-1Acid ingestionReceptor antagonistCitrate reabsorptionReceptor expressionCitrate excretionOpossum kidneyAcid loadB receptorAcid feedingPhysiological stimuliStimulationMice