2022
Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction.
Peng X, Kim J, Gupta G, Agaronyan K, Mankowski MC, Korde A, Takyar SS, Shin HJ, Habet V, Voth S, Audia JP, Chang D, Liu X, Wang L, Cai Y, Tian X, Ishibe S, Kang MJ, Compton S, Wilen CB, Dela Cruz CS, Sharma L. Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction. The Journal Of Immunology 2022, 209: 1314-1322. PMID: 36165196, PMCID: PMC9523490, DOI: 10.4049/jimmunol.2200198.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Bacterial infectionsMouse modelCoronavirus infectionLysosomal dysfunctionMajor health care challengeLung immune cellsLung tissue damageSecondary bacterial infectionImpair host immunityIL-1β releaseHealth care challengesCell deathPyroptotic cell deathBacterial killing abilityIL-1βBacterial clearanceImmune cellsSecondary infectionHost immunityAlveolar macrophagesTissue damageΒ-coronavirusStructural cellsCare challenges
2021
New Insights into the Immunity and Podocyte in Glomerular Health and Disease: From Pathogenesis to Therapy in Proteinuric Kidney Disease
Medina Rangel P, Priyadarshini A, Tian X. New Insights into the Immunity and Podocyte in Glomerular Health and Disease: From Pathogenesis to Therapy in Proteinuric Kidney Disease. Integrative Medicine In Nephrology And Andrology 2021, 8: 5. DOI: 10.4103/imna.imna_26_21.Peer-Reviewed Original ResearchProteinuric kidney diseaseKidney diseaseGlomerular injuryPodocyte injuryChronic kidney diseaseMillions of patientsAdaptive immune systemGlomerular filtration barrierImmune cellsImmune mechanismsTherapeutic implicationsTherapeutic targetGlomerular healthImmune systemInjuryComplement componentsDiseaseEpithelial cellsPodocytesFiltration barrierPresent reviewRecent findingsRecent studiesCellsPatients
2020
The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
Dong Z, Liu Z, Dai H, Liu W, Feng Z, Zhao Q, Gao Y, Liu F, Zhang N, Dong X, Zhou X, Du J, Huang G, Tian X, Liu B. The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy. Journal Of Immunology Research 2020, 2020: 7638365. PMID: 33426094, PMCID: PMC7772048, DOI: 10.1155/2020/7638365.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIdiopathic membranous nephropathyRegulatory B cellsBreg cellsMembranous nephropathyImmune responseB cellsPathogenesis of IMNDifferent inflammatory environmentsFunction of BregsPathological autoimmune responsesRole of BregsCellular immune responsesHumoral immune responseIMN patientsImmunomodulatory cellsImmunosuppressive roleAutoimmune responseInterleukin-10Autoimmune diseasesImmune cellsInflammatory environmentEarly treatmentT cellsBregsImmunological phenomena