2024
WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury
Wang Y, Cui C, Zhao W, Tian X, Liu P, Wei L, Zhu Z, Liu M, Fu R, Jia L. WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury. Immunobiology 2024, 229: 152832. PMID: 38943814, DOI: 10.1016/j.imbio.2024.152832.Peer-Reviewed Original ResearchAcute kidney injuryAcute tubular injuryLPS-induced acute kidney injuryHuman kidney 2Wip1 activityKidney injuryRenal tubulesUnilateral ischemia-reperfusion injurySepsis-associated acute kidney injuryRenal tubules of patientsHK2 cellsProtein levelsInduce acute injuryProximal renal tubulesWild-type p53-induced phosphatase 1Ischemia-reperfusion injuryPhosphorylation of p38 MAPKGSDMD-NHuman kidney-2 cellsSingle-cell sequencingPPM1D mRNAPhospho-p38 MAPKTubular injuryWip1 inhibitorScRNA-seqClinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series
Qu Y, Zhuang J, Duan Y, Baibutihan A, Maimaiti Z, Zhang C, Niu J, Teng W, Ailimu M, Wei X, Qi B, Li J, Du S, Wang D, Cao K, Wang J, Lu C, Tian X, Jiang H. Clinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series. Integrative Medicine In Nephrology And Andrology 2024, 11: e00019. DOI: 10.1097/imna-d-23-00019.Peer-Reviewed Original ResearchKidney transplant recipientsKT recipientsClinical characteristicsKidney transplantationTransplant recipientsElevated serum D-dimerIncidence of severe infectionsOmicron infectionSevere/critical illnessOutcomes of severe acute respiratory syndrome coronavirus 2Calcineurin inhibitor drugsSerum D-dimerSerum albumin levelSARS-CoV-2Acute kidney injuryFollow-up periodC-reactive proteinSARS-CoV-2 Omicron infectionSARS-CoV-2 Omicron variantReverse transcription polymerase chain reactionImmunocompromised statusFerritin levelsTranscription polymerase chain reactionSevere/critical groupAntiviral therapySuccessful outcome in a case of idiopathic multicentric Castleman disease with atypical lymphadenopathy and kidney injury: Diagnostic challenges and treatment approach—Case report
Yalikun D, Zhuang J, Lei W, Wang C, Aierken A, Qu Y, Wang J, Tian X, Jiang H. Successful outcome in a case of idiopathic multicentric Castleman disease with atypical lymphadenopathy and kidney injury: Diagnostic challenges and treatment approach—Case report. SAGE Open Medical Case Reports 2024, 12: 2050313x241240097. PMID: 38559411, PMCID: PMC10981217, DOI: 10.1177/2050313x241240097.Peer-Reviewed Case Reports and Technical NotesIdiopathic multicentric Castleman diseaseCastleman's diseaseMulticentric Castleman's diseaseSignificant lymphadenopathySystemic inflammationKidney injuryCases of idiopathic multicentric Castleman's diseaseMonths of follow-upLymph node biopsyUrinary tract infectionAnti-infective treatmentPatient's clinical symptomsAcute kidney injuryNo significant lymphadenopathyLoss of appetiteNode biopsySymptomatic recurrencePersistent feverTract infectionsMultiorgan involvementRenal functionDiagnostic challengeInflammatory markersCase reportFavorable outcome
2023
VPA improves ferroptosis in tubular epithelial cells after cisplatin-induced acute kidney injury
Li Y, Li K, Zhao W, Wang H, Xue X, Chen X, Li W, Xu P, Wang K, Liu P, Tian X, Fu R. VPA improves ferroptosis in tubular epithelial cells after cisplatin-induced acute kidney injury. Frontiers In Pharmacology 2023, 14: 1147772. PMID: 37153759, PMCID: PMC10155836, DOI: 10.3389/fphar.2023.1147772.Peer-Reviewed Original ResearchCisplatin-induced acute kidney injuryAcute kidney injuryAcyl-CoA synthetase long-chain family member 4Valproic acidKidney injuryTubular epithelial cellsGlutathione peroxidase 4Renal injuryDownregulation of GPX4Cisplatin-induced AKI miceCisplatin-induced renal injuryFer-1 treatmentEpithelial cellsBlood urea nitrogenCell deathFamily member 4AKI miceSerum creatinineAntiepileptic drugsHistone deacetylase 1Protective effectUrea nitrogenViable treatmentTissue damageCisplatin treatment