2014
Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission
Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ. Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission. American Journal Of Pathology 2014, 184: 2730-2741. PMID: 25239563, PMCID: PMC4188869, DOI: 10.1016/j.ajpath.2014.06.017.Peer-Reviewed Original ResearchConceptsActivation/apoptosisPulmonary emphysemaChronic obstructive pulmonary disease (COPD) lungsCigarette smoke-induced lung diseaseSmoke-induced lung diseaseChronic obstructive pulmonary diseaseDynamin-related protein 1Obstructive pulmonary diseaseProtein 1Mitochondrial fission protein dynamin-related protein 1Lung tissue sectionsCathepsin ENew therapeutic targetsAir space enlargementFission protein dynamin-related protein 1Pulmonary diseaseEmphysematous changesClinical entityLung diseaseMolecular mechanismsEmphysema developmentMitochondrial fissionLung parenchymaE miceLung elasticity
2006
Toll-like receptor 4 deficiency causes pulmonary emphysema
Zhang X, Shan P, Jiang G, Cohn L, Lee PJ. Toll-like receptor 4 deficiency causes pulmonary emphysema. Journal Of Clinical Investigation 2006, 116: 3050-3059. PMID: 17053835, PMCID: PMC1616193, DOI: 10.1172/jci28139.Peer-Reviewed Original ResearchConceptsToll-like receptor 4 deficiencyEndothelial cellsOxidant generationLung structural cellsAdoptive transfer experimentsNormal lung architectureDevelopment of emphysemaTLR4 deficiencyTLR4 expressionAirspace enlargementLung diseaseLung architecturePulmonary emphysemaLung integrityCigarette smokeLung elasticityEmphysemaNADPH inhibitorStructural cellsLungNovel NADPH oxidaseNADPH oxidaseElastolytic activityTLRMice