2024
Clinicopathologic features and prognosis of steatohepatitic hepatocellular carcinoma based on varying cutoffs of tumoral steatohepatitic changes
Zhang T, Niu N, Taddei T, Jain D, Zhang X. Clinicopathologic features and prognosis of steatohepatitic hepatocellular carcinoma based on varying cutoffs of tumoral steatohepatitic changes. American Journal Of Clinical Pathology 2024, aqae136. PMID: 39418121, DOI: 10.1093/ajcp/aqae136.Peer-Reviewed Original ResearchSH-HCCSteatohepatitic hepatocellular carcinomaHepatocellular carcinomaLiver diseaseHepatitis C virus infectionC virus infectionStage of fibrosisPresence of steatohepatitisOverall survivalHistological subtypesPrognostic factorsHCC subtypesBackground liverHCC casesClinicopathological featuresConventional HCCHistopathological patternsHyaline globulesTumor cellsMallory-Denk bodiesGlycogenated nucleiSteatotic liver diseaseHCCSurvival analysisSteatohepatitis
2023
Detection of Large-Droplet Macrovesicular Steatosis in Donor Livers Based on Segment-Anything Model
Tang H, Jiao J, Lin J, Zhang X, Sun N. Detection of Large-Droplet Macrovesicular Steatosis in Donor Livers Based on Segment-Anything Model. Laboratory Investigation 2023, 104: 100288. PMID: 37977550, DOI: 10.1016/j.labinv.2023.100288.Peer-Reviewed Original ResearchLiver diseaseMacrovesicular steatosisArtificial intelligence algorithmsArtificial intelligence modelsEnd-stage liver diseaseRule-based algorithmLiver histology analysisLiver transplant complicationsAcute liver failurePrimary hepatic malignancyLarge fat vacuolesIntelligence algorithmsDetection modelTransformer architectureIntelligence modelsTransplant complicationsLiver transplantationLiver failureLiver biopsyHepatic malignanciesFat vacuolesDonor organsEffective treatmentPrior knowledgeAlgorithmPostinfantile Giant Cell Hepatitis in Native and Allograft Livers: A Multi-Institutional Clinicopathologic Study of 70 Cases
Jiao J, Chezar K, Zhang X, Wang D, Cao W, Bindu C, Chen W, Neto A, Henn P, Riahi I, Wang H, Papke D, Zhao L, Xue Y, Liao X, Zhang X. Postinfantile Giant Cell Hepatitis in Native and Allograft Livers: A Multi-Institutional Clinicopathologic Study of 70 Cases. Modern Pathology 2023, 36: 100298. PMID: 37544363, DOI: 10.1016/j.modpat.2023.100298.Peer-Reviewed Original ResearchConceptsPostinfantile giant cell hepatitisAutoimmune liver diseaseGiant cell hepatitisAlkaline phosphatase levelsClinical outcomesPhosphatase levelsLiver diseaseMulti-institutional retrospective studyAssociated with better survivalAssociated with poor survivalClinicopathological characteristics of patientsAdverse prognostic factorAssociated with autoimmune liver diseasesGiant cellsVariable clinical outcomesFollow-up resultsCharacteristics of patientsDistribution of giant cellsOlder ageLiver disease etiologyPrognostic factorsAdvanced fibrosisBetter survivalClinicopathological characteristicsLiver allograftsInhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis
Luukkonen P, Sakuma I, Gaspar R, Mooring M, Nasiri A, Kahn M, Zhang X, Zhang D, Sammalkorpi H, Penttilä A, Orho-Melander M, Arola J, Juuti A, Zhang X, Yimlamai D, Yki-Järvinen H, Petersen K, Shulman G. Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2217543120. PMID: 36669104, PMCID: PMC9942818, DOI: 10.1073/pnas.2217543120.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseLiver fibrosisLiver diseaseCommon chronic liver diseaseChronic liver diseaseFatty liver diseaseRisk of fibrosisDistinct mouse modelsPyrimidine catabolismNonalcoholic steatohepatitisMouse modelTherapeutic targetFibrosisDihydropyrimidine dehydrogenaseHuman liverA variantCommon variantsMetabolomics approachDiseaseMiceInhibitionCatabolismKnockdownSteatohepatitisGimeracil
2022
The many faces and pathologic diagnostic challenges of autoimmune hepatitis
Zhang X, Jain D. The many faces and pathologic diagnostic challenges of autoimmune hepatitis. Human Pathology 2022, 132: 114-125. PMID: 35753409, DOI: 10.1016/j.humpath.2022.06.019.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisHistological featuresLiver diseaseAcute-onset autoimmune hepatitisDiagnosis of AIHEnd-stage liver diseaseChronic inflammatory liver diseasePathologic diagnostic challengeFatal liver failureInflammatory liver diseaseTypical histological featuresCareful clinicopathological correlationRoutine clinical practiceMajor differential diagnosisImmunosuppressive treatmentLiver histologySpecific autoantibodiesLiver failurePrompt diagnosisHistological presentationClinicopathological correlationInternational Working GroupPathological featuresDiagnostic challengeHistopathologic spectrum
2021
Hepatocellular Carcinoma
Jain A, Mazer B, Deng Y, Ciarleglio M, Jain D, Taddei T, Zhang X. Hepatocellular Carcinoma. American Journal Of Clinical Pathology 2021, 157: 305-313. PMID: 34542582, DOI: 10.1093/ajcp/aqab125.Peer-Reviewed Original ResearchConceptsAnaplastic tumor cellsHepatocellular carcinomaNoncirrhotic liverVascular invasionHistologic patternCirrhotic liverTumor cellsClear cell subtypePathogenesis of HCCHigh histologic gradeLarger tumor sizeHigher tumor stageHigh tumor gradeHigh rateHepatitis BHepatitis CLiver diseaseTumor sizeHistologic gradeTumor stageTumor gradePathologic differencesHCC casesRetrospective analysisPathology archives
2019
Clinical utility of genomic analysis in adults with idiopathic liver disease
Hakim A, Zhang X, DeLisle A, Oral EA, Dykas D, Drzewiecki K, Assis DN, Silveira M, Batisti J, Jain D, Bale A, Mistry PK, Vilarinho S. Clinical utility of genomic analysis in adults with idiopathic liver disease. Journal Of Hepatology 2019, 70: 1214-1221. PMID: 31000363, PMCID: PMC6526061, DOI: 10.1016/j.jhep.2019.01.036.Peer-Reviewed Original ResearchConceptsIdiopathic liver diseaseUnexplained liver diseaseManagement of adultsWhole-exome sequencingLiver diseaseAdult patientsUnknown etiologyHeterozygous variantsUse of WESAmelioration of dyslipidemiaDaily insulin requirementLeptin replacement therapyUtility of WESChronic liver diseaseNon-alcoholic steatohepatitisAcademic health care centerHealth care centersHomozygous pathogenic variantUnrelated adult patientsNon-oncological diseasesDisease preventive measuresInsulin requirementsLean patientsDevastating complicationLiver aminotransferases
2017
Non-alcoholic fatty liver disease: An expanded review
Benedict M, Zhang X. Non-alcoholic fatty liver disease: An expanded review. World Journal Of Hepatology 2017, 9: 715-732. PMID: 28652891, PMCID: PMC5468341, DOI: 10.4254/wjh.v9.i16.715.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseNAFLD patientsInsulin resistanceRisk factorsDevelopment of NAFLDTreatment of NAFLDFatty liver diseaseMedications/supplementsNumerous risk factorsNAFLD epidemiologyLiver transplantationCardiovascular mortalityLiver biopsySimple steatosisLiver diseaseMetabolic derangementsAssociated hepatitisDefinitive diagnosisPathologic changesFree fatty acidsAdvanced imagingLiver accumulationNatural historyProgressive steatosisGold standard
2014
Pathology of Alcoholic Liver Disease
Celli R, Zhang X. Pathology of Alcoholic Liver Disease. Journal Of Clinical And Translational Hepatology 2014, 2: 103-109. PMID: 26357621, PMCID: PMC4521259, DOI: 10.14218/jcth.2014.00010.Peer-Reviewed Original ResearchAlcoholic liver diseaseLiver diseaseAlcohol consumptionLiver-related deathAlcohol-attributable burdenImportant differential diagnosisSeverity of diseaseLiver biopsyPathologic featuresPathologic manifestationsDifferential diagnosisPopulation alcohol consumptionDiseaseGlobal healthClinical workBiopsyPatientsPathophysiologyCliniciansDiagnosisLiverPathologySeverity
2013
Histopathologic Manifestations of Drug-induced Hepatotoxicity
Zhang X, Ouyang J, Thung SN. Histopathologic Manifestations of Drug-induced Hepatotoxicity. Clinics In Liver Disease 2013, 17: 547-564. PMID: 24099017, DOI: 10.1016/j.cld.2013.07.004.Peer-Reviewed Original ResearchConceptsDrug-induced hepatotoxicityChronic liver diseaseLiver diseaseCareful medication historySpecific histopathologic patternAbnormal liver testsLiver testsResponsible drugSymptom onsetLiver injuryMedication historyCounter medicationsHistopathologic patternHistopathologic findingsDrug exposureHistopathologic manifestationsHepatobiliary diseaseCertain drugsSupplementary agentPrescription drugsHepatotoxicityHerbal productsLatent periodDiseaseDrugs