2014
A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis
Wu Y, O'Toole ET, Girard M, Ritter B, Messa M, Liu X, McPherson PS, Ferguson SM, De Camilli P. A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. ELife 2014, 3: e01621. PMID: 24963135, PMCID: PMC4107917, DOI: 10.7554/elife.01621.Peer-Reviewed Original ResearchConceptsClathrin-mediated endocytosisDynamin 1Bulk endosomesBulk endocytosisSynaptic vesiclesNew synaptic vesiclesClathrin-independent pathwaySynaptic vesicle recyclingSV membranesSV reformationDynamin 3Vesicle recyclingClathrinEndocytosisLarge endocytic vacuolesEndocytic vacuolesEndosomesPotent stimulationIntense synaptic activityVacuolesPathwaySynaptic activityMassive formationExocytosisBuds
2009
Increased anxiety‐like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2
Blundell J, Tabuchi K, Bolliger M, Blaiss C, Brose N, Liu X, Südhof T, Powell C. Increased anxiety‐like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2. Genes Brain & Behavior 2009, 8: 114-126. PMID: 19016888, PMCID: PMC2648807, DOI: 10.1111/j.1601-183x.2008.00455.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnxietyBehavior, AnimalBlotting, WesternCell Adhesion Molecules, NeuronalElectroshockGene DeletionInterpersonal RelationsLearningMaleMembrane ProteinsMiceMice, KnockoutMicroscopy, ElectronMotor ActivityNerve Tissue ProteinsPainPain MeasurementPostural BalanceSocial BehaviorSynapsesConceptsInhibitory synaptic functionInhibitory synaptic punctaAnxiety-like behaviorSynaptic functionInhibitory synapsesSynaptic punctaMutant miceInhibitory synapse numbersPostsynaptic cell adhesion moleculesBehavioral phenotypesSocial interaction deficitsSymmetric synapsesPain sensitivitySynapse numberCell adhesion moleculeNeuroligin-2Global deletionMiceAdhesion moleculesInteraction deficitsMarked increaseSynapsesBehavioral changesSynapse propertiesPuncta
2001
Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis
Sugita S, Han W, Butz S, Liu X, Fernández-Chacón R, Lao Y, Südhof T. Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis. Neuron 2001, 30: 459-473. PMID: 11395007, DOI: 10.1016/s0896-6273(01)00290-2.Peer-Reviewed Original ResearchMeSH KeywordsAgingAlternative SplicingAmino Acid SequenceAnimalsAnimals, NewbornBrainCalciumCalcium-Binding ProteinsCell MembraneCloning, MolecularEmbryo, MammalianExocytosisExonsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsLuminescent ProteinsMaleMembrane GlycoproteinsMiceMolecular Sequence DataNerve Tissue ProteinsOrgan SpecificityPC12 CellsRatsRecombinant Fusion ProteinsSequence AlignmentSequence Homology, Amino AcidSynapsesSynaptotagminsTransfectionConceptsSynaptotagmin VIIPlasma membraneNeuroendocrine PC12 cellsSynaptic vesiclesSynaptic vesicle exocytosisPlasma membrane Ca2Presynaptic active zoneVesicle exocytosisSynaptic exocytosisDependent exocytosisCentral synapsesRegulated patternSynaptotagmin IExocytosisMembrane Ca2SynaptotagminFusion partnerPC12 cellsNeuroendocrine cellsNeurotransmitter releasePotent inhibitorVesiclesActive zoneMembraneCells