Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis
Sugita S, Han W, Butz S, Liu X, Fernández-Chacón R, Lao Y, Südhof T. Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis. Neuron 2001, 30: 459-473. PMID: 11395007, DOI: 10.1016/s0896-6273(01)00290-2.Peer-Reviewed Original ResearchMeSH KeywordsAgingAlternative SplicingAmino Acid SequenceAnimalsAnimals, NewbornBrainCalciumCalcium-Binding ProteinsCell MembraneCloning, MolecularEmbryo, MammalianExocytosisExonsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsLuminescent ProteinsMaleMembrane GlycoproteinsMiceMolecular Sequence DataNerve Tissue ProteinsOrgan SpecificityPC12 CellsRatsRecombinant Fusion ProteinsSequence AlignmentSequence Homology, Amino AcidSynapsesSynaptotagminsTransfectionConceptsSynaptotagmin VIIPlasma membraneNeuroendocrine PC12 cellsSynaptic vesiclesSynaptic vesicle exocytosisPlasma membrane Ca2Presynaptic active zoneVesicle exocytosisSynaptic exocytosisDependent exocytosisCentral synapsesRegulated patternSynaptotagmin IExocytosisMembrane Ca2SynaptotagminFusion partnerPC12 cellsNeuroendocrine cellsNeurotransmitter releasePotent inhibitorVesiclesActive zoneMembraneCells