Nuclear localization of Klotho in brain: an anti-aging protein
German D, Khobahy I, Pastor J, Kuro-o M, Liu X. Nuclear localization of Klotho in brain: an anti-aging protein. Neurobiology Of Aging 2012, 33: 1483.e25-1483.e30. PMID: 22245317, PMCID: PMC3328593, DOI: 10.1016/j.neurobiolaging.2011.12.018.Peer-Reviewed Original ResearchConceptsExtracellular domainNuclear membraneSingle-pass transmembrane proteinMultiple fibroblast growth factor receptorsFibroblast growth factor receptorNuclear functionsPrecise cellular localizationTransmembrane proteinGrowth factor receptorNuclear localizationPlasma membraneTransmembrane formCellular localizationCell typesCultured cellsAnti-aging proteinCell membraneImmunoelectron microscopyLigand affinityWhole animalFactor receptorAntioxidant enzymesProteinKlotho proteinGenes