2024
N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia
Tong J, Yang K, Li W, Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Zhao Y, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Feng W, Tian B, Li C, Hong L, Tan Y. N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia. Schizophrenia Bulletin 2024, sbae180. PMID: 39406395, DOI: 10.1093/schbul/sbae180.Peer-Reviewed Original ResearchFirst-episode schizophreniaSensory gating deficitsN-methyl-D-aspartate receptorsFirst-episode schizophrenia groupGating deficitsN-methyl-D-aspartateP50 ratioSensory gatingExposure to antipsychotic medicationAb levelsHealthy controlsAntipsychotic medication exposureFirst-episode patientsDiagnosis of schizophreniaImpaired sensory gatingP50 sensory gating deficitN-methyl-D-aspartate receptor antibodiesAntipsychotic medicationFirst-episodeNon-smoking healthy controlsP50 differenceSchizophreniaPartial correlation analysisEnzyme-linked immunosorbent assayDeficitsThe Role of 3’ Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia
Guo X, Luo X, Huang X, Zhang Y, Ji J, Wang X, Wang K, Wang J, Pan X, Chen B, Tan Y, Luo X. The Role of 3’ Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia. Anatolian Journal Of Psychiatry 2024, 25: 413-420. PMID: 39148597, PMCID: PMC11322729, DOI: 10.5152/alphapsychiatry.2024.241616.Peer-Reviewed Original ResearchGray matter volumeAssociated with volumetric reductionsBasal gangliaSuperior frontal cortexDevelopment of schizophreniaSingle-nucleotide polymorphismsRisk of schizophreniaNucleus accumbensFrontal cortexPosterior cingulateMatter volumeInsular cortexBrain areasSchizophreniaSubcortical nucleiVolumetric reductionCortexPutamenCortical areasIndependent samplesRisk allelesSignificance of variantsRegulatory regionsMRNA expressionGenome-wide association studiesModifications on histone tails in Parkinson's disease.
Mao Q, Luo Z, Wang K, Chen B, Wang Z, Zhang Y, Wang X, Luo X. Modifications on histone tails in Parkinson's disease. SciBase Neurology 2024, 2 PMID: 39145143, PMCID: PMC11323098, DOI: 10.52768/neurology/1017.Peer-Reviewed Original ResearchHistone modificationsEpigenetic regulation of genesGene regulatory regionsGene expression regulationHistone tail modificationsRegulation of genesHistone marksChromatin structureRepressive marksRegulatory regionsExpression regulationHistone tailsTail modificationsHistone H2AEpigenetic modificationsEpigenetic regulationEpigenetic mechanismsHistoneGene expressionGenesGSK-J4Neural stem cellsA-synucleinEnvironmental factorsParkinson's diseaseRelationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
Wang X, Chen W, Gou M, Li W, Li N, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia. BMC Psychiatry 2024, 24: 480. PMID: 38956509, PMCID: PMC11218378, DOI: 10.1186/s12888-024-05796-y.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScalePlasma TNF-a levelsAgitation symptomsPANSS-ECEpisode patientsTNF-a levelsPositive and Negative Syndrome Scale total scorePANSS-EC scoreNegative Syndrome ScaleSymptoms of schizophreniaPathophysiology of schizophreniaEnzyme-linked immunosorbent assayTNF-aR1 levelSyndrome ScalePlasma levels of tumor necrosis factor-alphaLevels of tumor necrosis factor-alphaSchizophreniaTotal scoreTumor necrosis factor-alphaNecrosis factor-alphaPlasma TNF-aHealthy controlsFEPImmune abnormalitiesPhenome-wide association studies of TXNRD2-COMT-ARVCF cluster pinpoint schizophrenia and bipolar disorder
Guo X, Luo X, Zhang Y, Yu Z, Tan Z, Cao L, Ji J, Wang X, Wang K, Wang Z, Li C, Tan Y, Luo X. Phenome-wide association studies of TXNRD2-COMT-ARVCF cluster pinpoint schizophrenia and bipolar disorder. Asian Journal Of Psychiatry 2024, 98: 104145. PMID: 38959548, DOI: 10.1016/j.ajp.2024.104145.Peer-Reviewed Original ResearchMachine Learning-Based Prediction of Binge Drinking among Adults in the United State: Analysis of the 2022 Health Information National Trends Survey
Huang X, Dai Z, Wang K, Luo X. Machine Learning-Based Prediction of Binge Drinking among Adults in the United State: Analysis of the 2022 Health Information National Trends Survey. 2024, 1-10. DOI: 10.1145/3670085.3670090.Peer-Reviewed Original ResearchHealth Information National Trends SurveyNational Trends SurveySupport vector machineTrends SurveyBinge drinkingMachine learningMultiple health behaviour interventionsRisk factors of binge drinkingHealth behavior interventionsImprove health outcomesPrevalence of binge drinkingK-nearest neighborHealth outcomesSocial mediaTobacco useU.S. adultsRadial basis functionBehavioral interventionsUnited StatesAlcohol useNaive BayesFeature selectionLogistic regressionK-nearestMachine learning-based predictionSerum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders
Li Y, Wang L, Huang J, Zhang P, Zhou Y, Tong J, Chen W, Gou M, Tian B, Li W, Luo X, Tian L, Hong L, Li C, Tan Y. Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders. Frontiers In Psychiatry 2024, 15: 1357293. PMID: 38680780, PMCID: PMC11046465, DOI: 10.3389/fpsyt.2024.1357293.Peer-Reviewed Original ResearchYoung Mania Rating ScaleBD-DAffective disordersBD-MDepressive symptomsHamilton Depression Scale-17 itemsRemission of depressive symptomsKynurenic acidMania Rating ScaleAcute manic episodeWeeks of antidepressantsRisk of MDDKynurenine pathwayAssociated with remissionAntipsychotic medicationDisrupt tryptophan metabolismManic symptomsDepressive disorderBD-D.Depressive episodeHAMD-17Mood stabilizersManic episodesBipolar disorderTryptophan pathwayCorrelation of allostatic load and perceived stress with clinical features in first-episode schizophrenia
Zhou Y, Wang L, Yang K, Huang J, Li Y, Li W, Zhang P, Fan F, Yin Y, Yu T, Chen S, Luo X, Tan S, Wang Z, Feng W, Tian B, Tian L, Li C, Tan Y. Correlation of allostatic load and perceived stress with clinical features in first-episode schizophrenia. Journal Of Psychiatric Research 2024, 172: 156-163. PMID: 38382239, DOI: 10.1016/j.jpsychires.2024.02.025.Peer-Reviewed Original ResearchFirst-episode schizophreniaCalgary Depression Scale for SchizophreniaPositive and Negative Syndrome ScalePerceived stressPositive symptomsAllostatic loadPSS scoresSeverity of positive symptomsClinical features of schizophreniaNegative Syndrome ScaleFeatures of schizophreniaChronic physiological stressAssociated with depressive symptomsEtiology of schizophreniaAssess subjective stressOccurrence of schizophreniaHealthy controlsPerceived Stress Scale-14Clinical featuresCDSS scoresSyndrome ScaleDepressive symptomsSchizophreniaSubjective stressStressor typeDoes Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder?
Jiao Q, Dong Y, Ma X, Ji S, Liu X, Zhang J, Sun X, Li D, Luo X, Zhang Y. Does Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder? Neuropsychiatric Disease And Treatment 2024, 20: 353-361. PMID: 38415074, PMCID: PMC10898600, DOI: 10.2147/ndt.s453447.Peer-Reviewed Original ResearchHDRS-17 total scoreFunctioning Assessment Short TestMATRICS Consensus Cognitive BatteryMajor depressive disorderHDRS-17FED patientsCPT-IPCognitive functionBaseline cognitive functionTotal scoreDepressive disorderFirst-episodeDrug-naivePatients' responses to antidepressant treatmentFunctioning Assessment Short Test total scoreResponse to antidepressant treatmentHamilton Depression Rating ScaleFunctioning Assessment Short Test scoreConsensus Cognitive BatteryDepression Rating ScaleAssociated with worse cognitive functionSpeed of processingHamilton Anxiety ScaleDrug-naive patientsInterpersonal relationship domain
2023
Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence
Yang K, Du R, Yang Q, Zhao R, Fan F, Chen S, Luo X, Tan S, Wang Z, Yu T, Tian B, Le T, Li C, Tan Y. Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence. Brain Imaging And Behavior 2023, 18: 331-342. PMID: 38078981, DOI: 10.1007/s11682-023-00838-7.Peer-Reviewed Original ResearchRNA m6A methylation in psychiatric disorders.
Mao Q, Luo J, Luo X, Zhu X, Wang K, Zuo L, Zhang Y, Luo X. RNA m6A methylation in psychiatric disorders. EC Psychology And Psychiatry 2023, 12 PMID: 38145106, PMCID: PMC10745284.Peer-Reviewed Original ResearchMajor psychiatric disordersPsychiatric disordersM6A modificationM6A methyltransferase METTL3Synaptic protein synthesisInflammatory infiltrationImmune infiltrationRNA m6A methylationTherapeutic targetM6A regulatorsAlzheimer's diseaseNeuropsychiatric disordersMethyltransferase METTL3Subtype classificationPromising targetDiseaseDisordersM6A methylationInfiltrationCritical roleProtein synthesisReviewPathogenesisComprehensive reviewPreventionCorrelation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia
Gou M, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Li C, Zhang P, Huang J, Tian L, Hong L, Tan Y. Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia. Molecular Neurobiology 2023, 61: 2754-2763. PMID: 37932545, DOI: 10.1007/s12035-023-03694-0.Peer-Reviewed Original ResearchImmune-inflammatory response systemWhite matter integrityEnzyme-linked immunosorbent assayDiffusion tensor imagingD effect sizesFractional anisotropyWhole-brain white matter integritySex-matched healthy controlsReflex systemPlasma cytokine levelsFirst-episode patientsBrains of patientsBrain white matter integrityCortico-spinal tractNegative Syndrome ScaleCohen's d effect sizesAverage fractional anisotropyImmune imbalancePeripheral cytokinesCytokine levelsInflammatory mediatorsEpisode patientsPathophysiological mechanismsWhite matter microstructureFunctional dysconnectivityRegional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study
Yu T, Li Y, Li N, Huang J, Fan F, Luo X, Tan S, Yang F, Tian B, Tian L, Li C, Tan Y. Regional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study. Psychiatry Research Neuroimaging 2023, 335: 111724. PMID: 37871408, DOI: 10.1016/j.pscychresns.2023.111724.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaInferior semilunar lobuleSchizophrenia patientsCourse of TDRegional homogeneityResting-state functional magnetic resonance imagingResting-state fMRI studySeverity of TDCerebral regional homogeneityUpper limb scoreNegative Syndrome ScaleNon-TD groupMedial frontal gyrusFunctional magnetic resonance imagingMagnetic resonance imagingLower ReHoReHo valuesHigher ReHoLimb scoreNeuronal degenerationHealthy controlsFunctional abnormalitiesMovement ScaleLeft supramarginal gyrusImmune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia
Gou M, Chen W, Li Y, Chen S, Feng W, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Zhou Y, Li H, Yu T, Wang Z, Zhang P, Huang J, Kochunov P, Tian L, Li C, Hong L, Tan Y. Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia. Schizophrenia Bulletin 2023, 50: 199-209. PMID: 37540273, PMCID: PMC10754202, DOI: 10.1093/schbul/sbad114.Peer-Reviewed Original ResearchConceptsImmune-inflammatory response systemWhite matter integrityNegative symptom scoresFractional anisotropySymptom scoresAffected white matter tractsImmune inflammatory responsePanel of cytokinesWhite matter impairmentEnzyme-linked immunosorbentWhite matter tractsAverage fractional anisotropyWhite matter componentsPeripheral inflammationNeuroinflammatory conditionsPathophysiological mechanismsHealthy controlsCorpus callosumNegative symptomsReflex systemSchizophreniaOligodendrocyte differentiationConsistent findingComposite scoreUnderlying mechanismSerum BDNF levels and state anxiety are associated with somatic symptoms in patients with panic disorder
Li J, Li R, Li D, Zhang J, Luo X, Zhang Y. Serum BDNF levels and state anxiety are associated with somatic symptoms in patients with panic disorder. Frontiers In Psychiatry 2023, 14: 1168771. PMID: 37533888, PMCID: PMC10393281, DOI: 10.3389/fpsyt.2023.1168771.Peer-Reviewed Original ResearchPanic Disorder Severity Scale-Chinese VersionSerum BDNF levelsState-Trait Anxiety InventoryBDNF levelsSomatic symptomsPanic disorderPHQ-15State anxietyPD patientsSerum BDNFBaseline serum BDNF levelsHealthy controlsAssociated with somatic symptomsAnxiety-related symptomsAnxiety-related variablesMeasure somatic symptomsPHQ-15 scoresEscitalopram treatmentPanic severityAssess panicNinety PD patientsState-TraitAnxiety InventoryPanicPartial correlation analysisChanges in Inflammatory Biomarkers in Patients with Schizophrenia: A 3-Year Retrospective Study
Zhu X, Li R, Zhu Y, Zhou J, Huang J, Zhou Y, Tong J, Zhang P, Luo X, Chen S, Li Y, Tian B, Tan S, Wang Z, Han X, Tian L, Li C, Tan Y. Changes in Inflammatory Biomarkers in Patients with Schizophrenia: A 3-Year Retrospective Study. Neuropsychiatric Disease And Treatment 2023, 19: 1597-1604. PMID: 37465565, PMCID: PMC10350427, DOI: 10.2147/ndt.s411028.Peer-Reviewed Original ResearchSystemic immune-inflammation indexMonocyte/lymphocyte ratioNeutrophil/lymphocyte ratioPlatelet/lymphocyte ratioLymphocyte ratioLYM countSex-matched healthy participantsComplete blood count dataContinuous antipsychotic treatmentPathophysiology of schizophreniaImmune system activationLinear mixed modelsBlood count dataImpact of ageInflammatory hypothesisInflammatory biomarkersNeutrophil countAntipsychotic treatmentInflammatory stateRetrospective studyHealthy controlsSystem activationPatientsFull courseSchizophrenia diagnosisA novel risk variant block across introns 36–45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study
Guo X, Wang S, Lin X, Wang Z, Dou Y, Cao Y, Zhang Y, Luo X, Kang L, Yu T, Wang Z, Tan Y, Gao S, Zheng H, Zhao F, Wang H, Wang K, Xie F, Chen W, Luo X. A novel risk variant block across introns 36–45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study. Psychiatric Genetics 2023, 33: 182-190. PMID: 37706495, PMCID: PMC10502955, DOI: 10.1097/ypg.0000000000000344.Peer-Reviewed Original ResearchConceptsGray matter volumeBrain regionsMRNA expressionSubcortical structuresPathogenesis of schizophreniaRisk variantsRisk genesMultiple brain regionsCortical surface areaPotential regulatory effectsHealthy subjectsMatter volumeSignificant associationCortical regionsSame effect directionSchizophreniaNovel risk variantsSchizophrenia risk allelesAssociation studiesCACNA1CIndependent samplesRegulatory effectsNumerous genome-wide association studiesTop risk genesValidation studyPleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders
Wang Z, Lin X, Luo X, Xiao J, Zhang Y, Xu J, Wang S, Zhao F, Wang H, Zheng H, Zhang W, Lin C, Tan Z, Cao L, Wang Z, Tan Y, Chen W, Cao Y, Guo X, Pittenger C, Luo X. Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders. Schizophrenia Bulletin 2023, 49: 1174-1184. PMID: 37306960, PMCID: PMC10483336, DOI: 10.1093/schbul/sbad073.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderNeuropsychiatric disordersIntracranial volumeSingle nucleotide polymorphismsParkinson's diseaseCACNA1C variantsCACNA1C mRNARisk allelesAlcohol use disorderAverage cortical thicknessTotal intracranial volumeMultiple psychiatric disordersFalse discovery rate correctionDifferent neuropsychiatric disordersCortical surface areaBrain cohortCortical thicknessIndependent cohortPsychiatric disordersUse disordersMatter volumeSubcortical structuresSubstance dependenceDiseaseSpatial Multiomics Analysis in Psychiatric Disorders.
Mao Q, Huang S, Luo X, Liu P, Wang X, Wang K, Zhang Y, Chen B, Luo X. Spatial Multiomics Analysis in Psychiatric Disorders. EC Psychology And Psychiatry 2023, 12: 1-5. PMID: 37424930, PMCID: PMC10328214.Peer-Reviewed Original ResearchPsychiatric disordersAlzheimer's diseaseCommon psychiatric disordersCertain brain regionsRisk genesMiddle temporal gyrusMultiomics analysisAutism spectrum disorderAD pathologyDisease progressionOlfactory bulbSpectrum disorderMouse modelPsychiatric diseasesHuman hippocampusBrain regionsNeuropsychiatric disordersTemporal gyrusLiterature searchAid diagnosisDisordersTranscriptional signatureDiseaseHippocampusSpatial transcriptomic analysisInflammatory disequilibrium and lateral ventricular enlargement in treatment-resistant schizophrenia
Chen W, Gou M, Wang L, Li N, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Inflammatory disequilibrium and lateral ventricular enlargement in treatment-resistant schizophrenia. European Neuropsychopharmacology 2023, 72: 18-29. PMID: 37058967, DOI: 10.1016/j.euroneuro.2023.03.014.Peer-Reviewed Original ResearchConceptsAnti-inflammatory cytokinesInflammatory disequilibriumImmune-inflammatory response systemPlasma cytokine levelsTreatment-resistant schizophreniaLateral ventricular enlargementLarger lateral ventricle volumesPro-inflammatory cytokinesLateral ventricle volumeNegative Syndrome ScalePotential pathophysiological processesEnzyme-linked immunosorbentHigher PANSS scoresImmune imbalanceCytokine levelsT helperInflammatory imbalanceImmune biomarkersVentricular enlargementClinical manifestationsRegulatory cytokinesHealthy controlsPANSS scoresTh-17Subcortical volumes