2008
Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations
Luo X, Zuo L, Kranzler H, Zhang H, Wang S, Gelernter J. Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2008, 147B: 1028-1039. PMID: 18213616, PMCID: PMC3162230, DOI: 10.1002/ajmg.b.30701.Peer-Reviewed Original Research
2006
Association between two µ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence
Zhang H, Luo X, Kranzler HR, Lappalainen J, Yang BZ, Krupitsky E, Zvartau E, Gelernter J. Association between two µ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Human Molecular Genetics 2006, 15: 807-819. PMID: 16476706, PMCID: PMC3164878, DOI: 10.1093/hmg/ddl024.Peer-Reviewed Original Research
2005
Response to Dr. Kopke's comments on haplotypes at the OPRM1 locus
Luo X, Gelernter J, Zhao H, Kranzler HR. Response to Dr. Kopke's comments on haplotypes at the OPRM1 locus. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 135B: 102-102. PMID: 15806579, DOI: 10.1002/ajmg.b.30060.Peer-Reviewed Original Research
2003
Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European‐Americans
Luo X, Kranzler HR, Zhao H, Gelernter J. Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European‐Americans. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 120B: 97-108. PMID: 12815747, DOI: 10.1002/ajmg.b.20034.Peer-Reviewed Original ResearchAlcoholismBlack PeopleCocaine-Related DisordersExonsFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenotypeHaplotypesHumansLinkage DisequilibriumMaleOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, Opioid, muSubstance-Related DisordersUnited StatesWhite PeopleAssociation between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the μ‐opioid receptor locus (OPRM1)
Hernandez‐Avila C, Wand G, Luo X, Gelernter J, Kranzler HR. Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the μ‐opioid receptor locus (OPRM1). American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 118B: 60-65. PMID: 12627468, DOI: 10.1002/ajmg.b.10054.Peer-Reviewed Original ResearchConceptsCortisol responseAsn40 alleleAsn40Asp polymorphismAsp40 alleleCortisol concentrationsCortisol time curveMu-opioid receptor proteinOpioid antagonist naloxoneMin post infusionPeak cortisol responsePlasma ACTH concentrationsEnhanced cortisol responseHigher cortisol concentrationsWarrants further investigationAsp40 variantIntravenous naloxoneOpioid blockadeNaloxone infusionAntagonist naloxonePlasma ACTHACTH concentrationsAgonist effectsPost infusionHealthy subjectsClinical relevance