Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury
Cao Y, Gao Y, Xu S, Bao J, Lin Y, Luo X, Wang Y, Luo Q, Jiang J, Neale JH, Zhong C. Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury. BMC Neuroscience 2016, 17: 15. PMID: 27091009, PMCID: PMC4836105, DOI: 10.1186/s12868-016-0251-1.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryWild-type miceBrain injuryKnockout miceNeuroprotective efficacyType miceImpact injuryOxidative stressCortical impact injuryInjury-induced increaseBcl-2/Bax ratioGene knockout miceGlutathione peroxidase activityCerebral cortexCortical apoptosisKO miceCytosolic cytochrome c levelsConclusionsThese dataN-acetylaspartylglutamateSynaptic releaseTUNEL-positive nucleiAnimal modelsExtracellular levelsCytochrome c levelsGlutathione levels