2019
Precise spatio-temporal interruption of regulatory T cell-mediated CD8+ T cell suppression leads to tumor immunity
Zhou X, Zhao S, He Y, Geng S, Shi Y, Wang B. Precise spatio-temporal interruption of regulatory T cell-mediated CD8+ T cell suppression leads to tumor immunity. Cancer Research 2019, 79: canres.1250.2018. PMID: 30254146, DOI: 10.1158/0008-5472.can-18-1250.Peer-Reviewed Original ResearchConceptsTumor-draining lymph nodesRegulatory T cellsT cellsStrong tumor-suppressive effectSphingosine-1-phosphate receptor 1Low systemic side effectsT cell activityT cell suppressionSignificant tumor reductionSystemic side effectsAntitumor immune activationTumor-suppressive effectsDraining lymphMinimal blockadeTreg ablationTreg inhibitionLymph nodesTumor immunityTumor inoculationClinical evidenceImmune activationImmune suppressionTumor reductionCD8Cell suppression
2015
Herpes Simplex Virus 1 Suppresses the Function of Lung Dendritic Cells via Caveolin-1
Wu B, Geng S, Bi Y, Liu H, Hu Y, Li X, Zhang Y, Zhou X, Zheng G, He B, Wang B. Herpes Simplex Virus 1 Suppresses the Function of Lung Dendritic Cells via Caveolin-1. MSphere 2015, 22: 883-895. PMID: 26018534, PMCID: PMC4519715, DOI: 10.1128/cvi.00170-15.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseDendritic cellsHSV-1 infectionCav-1HSV-1Nitric oxideHerpes simplex virus 1 (HSV-1) infectionLung dendritic cellsSimplex virus 1 infectionLung pathological changesCav-1 knockout miceNitric oxide synthaseVirus-1 infectionWild-type miceHost antiviral responseHerpes simplex virus 1Cav-1 deficiencySimplex virus 1Adoptive transferCaveolin-1Cav-1 knockdownINOS inhibitorOxide synthasePathological changesTherapeutic approaches