2018
Prostate cancer risk factors in black and white men in the NIH-AARP Diet and Health Study
Layne TM, Graubard BI, Ma X, Mayne ST, Albanes D. Prostate cancer risk factors in black and white men in the NIH-AARP Diet and Health Study. Prostate Cancer And Prostatic Diseases 2018, 22: 91-100. PMID: 30108373, PMCID: PMC6676904, DOI: 10.1038/s41391-018-0070-9.Peer-Reviewed Original ResearchConceptsProstate cancer riskHazard ratioWhite menAdvanced diseaseBlack raceRisk factorsCancer riskHealth StudyRisk associationDietary vitamin D intakeProstate cancer risk factorsProportional hazards regression modelsBlack menNon-Hispanic white menPositive risk associationVitamin D intakeHistory of diabetesNIH-AARP DietCancer risk factorsProstate cancer screeningHazards regression modelsConfidence intervalsHealth-related factorsCancer risk associationsRace-specific associationsRegional Practice Patterns and Racial/Ethnic Differences in Intensity of End‐of‐Life Care
Wang S, Hsu SH, Huang S, Doan KC, Gross CP, Ma X. Regional Practice Patterns and Racial/Ethnic Differences in Intensity of End‐of‐Life Care. Health Services Research 2018, 53: 4291-4309. PMID: 29951996, PMCID: PMC6232508, DOI: 10.1111/1475-6773.12998.Peer-Reviewed Original ResearchConceptsIntensity of endHospital referral regionsRegional practice patternsPractice patternsLife careEthnic differencesLife care expendituresLocal practice patternsCancer decedentsMedicare databaseRacial/Ethnic DifferencesReferral regionsCare expendituresCareEnd resultDifferencesEpidemiologyDecedents
2016
In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia
Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood 2016, 129: 1680-1684. PMID: 27979823, PMCID: PMC5364339, DOI: 10.1182/blood-2016-07-723148.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCMV infectionCytomegalovirus infectionLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaUtero cytomegalovirus infectionCongenital CMV infectionCommon childhood cancerActive viral transcriptionBone marrow specimensNon-Hispanic whitesTiming of infectionNewborn blood samplesEtiologic roleRisk factorsChildhood cancerHealthy controlsHigh prevalenceMarrow specimensLeukemia blastsBlood samplesPrenatal originEtiologic agentInfectionHispanic children
2012
HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk
Urayama KY, Chokkalingam AP, Metayer C, Ma X, Selvin S, Barcellos LF, Wiemels JL, Wiencke JK, Taylor M, Brennan P, Dahl GV, Moonsamy P, Erlich HA, Trachtenberg E, Buffler PA. HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk. Blood 2012, 120: 3039-3047. PMID: 22923493, PMCID: PMC3471514, DOI: 10.1182/blood-2012-01-404723.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCase-Control StudiesChildChild, PreschoolFemaleGenetic Predisposition to DiseaseGenetic VariationGenotypeHispanic or LatinoHLA-DP alpha-ChainsHLA-DP beta-ChainsHumansImmunologic FactorsInfantMalePrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosisRisk FactorsWhite PeopleYoung AdultConceptsAcute lymphoblastic leukemiaImmune modulationChildhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemia riskAcute lymphoblastic leukemia riskEarly immune modulationHuman leukocyte antigen (HLA) genesLowest exposure categoryLogistic regression analysisEtiology of childhoodNon-Hispanic whitesHLA-DPB1 geneRace/ethnicityInfectious exposureLymphoblastic leukemiaImmune mechanismsExposure categoriesHispanic ethnicityLeukemia riskGenetic susceptibility lociHLA-DPA1Immune systemHispanic childrenRegression analysisEvidence of interaction
2006
Cytogenetics of Hispanic and White Children with Acute Lymphoblastic Leukemia in California
Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. Cytogenetics of Hispanic and White Children with Acute Lymphoblastic Leukemia in California. Cancer Epidemiology Biomarkers & Prevention 2006, 15: 578-581. PMID: 16537719, DOI: 10.1158/1055-9965.epi-05-0833.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge DistributionCaliforniaChildChild, PreschoolCohort StudiesCore Binding Factor Alpha 2 SubunitCytogeneticsFemaleGene Expression Regulation, NeoplasticGenetic MarkersGenetic Predisposition to DiseaseHispanic or LatinoHumansIn Situ Hybridization, FluorescenceIncidenceInfantMaleOncogene Proteins, FusionPloidiesPrecursor Cell Lymphoblastic Leukemia-LymphomaProbabilityProspective StudiesRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSex DistributionSurvival RateWhite PeopleConceptsAcute lymphoblastic leukemia patientsNon-Hispanic whitesLymphoblastic leukemia patientsLeukemia patientsB-lineage acute lymphoblastic leukemia patientsNorthern California Childhood Leukemia StudyPopulation-based studyAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyChildhood Leukemia StudyChildhood leukemia patientsEthnic-specific risk factorsTEL-AML1 translocationSitu hybridization findingsTumor genetic characteristicsLymphoblastic leukemiaRisk factorsEpidemiologic studiesHigh hyperdiploidyTEL-AML1Childhood leukemiaCytogenetic profilePatientsMLL rearrangementsLeukemia Study
2005
Ethnic Difference in Daycare Attendance, Early Infections, and Risk of Childhood Acute Lymphoblastic Leukemia
Ma X, Buffler PA, Wiemels JL, Selvin S, Metayer C, Loh M, Does MB, Wiencke JK. Ethnic Difference in Daycare Attendance, Early Infections, and Risk of Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiology Biomarkers & Prevention 2005, 14: 1928-1934. PMID: 16103439, DOI: 10.1158/1055-9965.epi-05-0115.Peer-Reviewed Original ResearchConceptsNon-Hispanic white childrenAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaDaycare attendanceLymphoblastic leukemiaC-ALLOdds ratioEarly infectionWhite childrenNorthern California Childhood Leukemia StudyPossible etiologic roleRisk of childhoodEthnic differencesCalifornia Childhood Leukemia StudyChildhood Leukemia StudyDose-response relationshipImportant ethnic differencesEar infectionsEtiologic roleInfectious agentsMagnitude of effectInfectionDisease hypothesisLeukemia StudyHispanic childrenRAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia
Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia 2005, 19: 415-419. PMID: 15674422, DOI: 10.1038/sj.leu.2403641.Peer-Reviewed Original ResearchConceptsRAS mutationsMaternal ageLeukemia casesPediatric acute lymphoblastic leukemiaAcute lymphoblastic leukemia casesDiagnostic bone marrow samplesIncident leukemia casesPaternal preconception smokingNorthern California Childhood Leukemia StudyAcute lymphoblastic leukemiaLymphoblastic leukemia casesBone marrow samplesKRAS codon 12California Childhood Leukemia StudyRAS gene mutationsChildhood Leukemia StudyEtiology of subtypesPreconception smokingCase seriesLymphoblastic leukemiaLeukemia patientsMultivariable modelMarrow samplesHigh hyperdiploidyChildhood leukemia