2021
Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia
Whitehead TP, Wiemels JL, Zhou M, Kang AY, McCoy LS, Wang R, Fitch B, Petrick LM, Yano Y, Imani P, Rappaport SM, Dahl GV, Kogan SC, Ma X, Metayer C. Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1526-1535. PMID: 34078642, PMCID: PMC8338848, DOI: 10.1158/1055-9965.epi-20-1704.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCytokine levelsLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAberrant immune reactionsPrenatal immune developmentRisk of childhoodInterquartile range incrementAltered cytokine levelsCalifornia Childhood Leukemia StudyChildhood Leukemia StudyBirth characteristicsNeonatal levelsPrenatal exposureImmunomodulatory cytokinesImmune developmentHigh hyperdiploidyImmune reactionsCytokinesGM-CSFBlood spotsLogistic regressionLeukemia StudyEndogenous metabolitesConfidence intervals
2016
In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia
Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood 2016, 129: 1680-1684. PMID: 27979823, PMCID: PMC5364339, DOI: 10.1182/blood-2016-07-723148.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCMV infectionCytomegalovirus infectionLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaUtero cytomegalovirus infectionCongenital CMV infectionCommon childhood cancerActive viral transcriptionBone marrow specimensNon-Hispanic whitesTiming of infectionNewborn blood samplesEtiologic roleRisk factorsChildhood cancerHealthy controlsHigh prevalenceMarrow specimensLeukemia blastsBlood samplesPrenatal originEtiologic agentInfectionHispanic children
2003
Prenatal origin of TEL‐AML1–positive acute lymphoblastic leukemia in children born in California
McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Guo W, Loh ML, Smith MT. Prenatal origin of TEL‐AML1–positive acute lymphoblastic leukemia in children born in California. Genes Chromosomes And Cancer 2003, 37: 36-43. PMID: 12661004, DOI: 10.1002/gcc.10199.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCommon acute lymphoblastic leukemiaLymphoblastic leukemiaTEL-AML1CALL patientsPrenatal originTEL-AML1 gene fusionGuthrie cardsPositive acute lymphoblastic leukemiaSecondary changesTime of diagnosisTEL-AML1 fusionNeonatal Guthrie cardsNeonatal blood spotsClonotypic primersClonotypic sequencesOlder patientsPeak incidenceChildhood cancerRetrospective analysisTEL alleleTrisomy 21Blood spotsLeukemiaPatients