2019
The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies
Wiemels J, Muskens I, Li S, Pandey P, Roy R, Hansen H, Siegmund K, Mueller B, Ma X, Metayer C, de Smith A. The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies. Blood 2019, 134: 2510. DOI: 10.1182/blood-2019-131455.Peer-Reviewed Original ResearchTransient abnormal myelopoiesisNon-DS subjectsDS neonatesDown syndromeTrisomy 21Hematopoietic stem cellsBlood cell proportionsT cellsHigher CD8 T cellsCell proportionEpigenome-wide association studiesMean beta valueNon-DS controlsCD8 T cellsCD4 T cellsLow B cellsAcute lymphoblastic leukemiaAcute megakaryoblastic leukemiaMulti-Ethnic StudyNeonatal DNA methylationEthnicity-stratified analysisSignificant DMRsIllumina Infinium MethylationEPIC arrayChromosome 21Non-Latino whites
2003
Prenatal origin of TEL‐AML1–positive acute lymphoblastic leukemia in children born in California
McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Guo W, Loh ML, Smith MT. Prenatal origin of TEL‐AML1–positive acute lymphoblastic leukemia in children born in California. Genes Chromosomes And Cancer 2003, 37: 36-43. PMID: 12661004, DOI: 10.1002/gcc.10199.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCommon acute lymphoblastic leukemiaLymphoblastic leukemiaTEL-AML1CALL patientsPrenatal originTEL-AML1 gene fusionGuthrie cardsPositive acute lymphoblastic leukemiaSecondary changesTime of diagnosisTEL-AML1 fusionNeonatal Guthrie cardsNeonatal blood spotsClonotypic primersClonotypic sequencesOlder patientsPeak incidenceChildhood cancerRetrospective analysisTEL alleleTrisomy 21Blood spotsLeukemiaPatients