2013
Repeated in vivo exposure of cocaine induces long‐lasting synaptic plasticity in hypocretin/orexin‐producing neurons in the lateral hypothalamus in mice
Rao Y, Mineur YS, Gan G, Wang AH, Liu Z, Wu X, Suyama S, de Lecea L, Horvath TL, Picciotto MR, Gao X. Repeated in vivo exposure of cocaine induces long‐lasting synaptic plasticity in hypocretin/orexin‐producing neurons in the lateral hypothalamus in mice. The Journal Of Physiology 2013, 591: 1951-1966. PMID: 23318871, PMCID: PMC3624862, DOI: 10.1113/jphysiol.2012.246983.Peer-Reviewed Original ResearchConceptsCAMP response element-binding proteinHypocretin neuronsLong-term potentiationSynaptic potentiationLateral hypothalamusCocaine administrationExperience-dependent synaptic potentiationExperience-dependent potentiationHypocretin-producing neuronsVivo cocaine administrationCocaine-treated animalsOrexin-producing neuronsAMPA-type glutamate receptorsVentral tegmental areaHigh-frequency stimulationCocaine-treated micePlace preference protocolResponse element-binding proteinDrugs of abuseCocaine withdrawalTegmental areaGlutamatergic synapsesGlutamate receptorsHypocretin systemElement-binding protein
2001
Membrane Properties Underlying Patterns of GABA-Dependent Action Potentials in Developing Mouse Hypothalamic Neurons
Wang Y, Gao X, van den Pol A. Membrane Properties Underlying Patterns of GABA-Dependent Action Potentials in Developing Mouse Hypothalamic Neurons. Journal Of Neurophysiology 2001, 86: 1252-1265. PMID: 11535674, DOI: 10.1152/jn.2001.86.3.1252.Peer-Reviewed Original ResearchConceptsHypothalamic neuronsAction potentialsMouse hypothalamusMultiple spikesSpike thresholdFrequency of GABAMediobasal hypothalamic neuronsProbability of GABAGlutamate receptor antagonistsConventional whole cellMouse hypothalamic neuronsMultiple action potentialsPostnatal day 2Intrinsic membrane propertiesMean reversal potentialIonotropic glutamate receptorsSimilar spike patternsPeaks of depolarizationGABA excitationMembrane potentialReceptor antagonistSpike patternsExcitatory activityGlutamate receptorsSynaptic transmission
1998
GABA-Dependent Firing of Glutamate-Evoked Action Potentials at AMPA/Kainate Receptors in Developing Hypothalamic Neurons
Gao X, Chen G, van den Pol A. GABA-Dependent Firing of Glutamate-Evoked Action Potentials at AMPA/Kainate Receptors in Developing Hypothalamic Neurons. Journal Of Neurophysiology 1998, 79: 716-726. PMID: 9463435, DOI: 10.1152/jn.1998.79.2.716.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidAction potentialsHypothalamic neuronsAMPA/kainate receptorsN-methyl-D-aspartate receptorsGlutamate-mediated excitationAdult mammalian CNSFire action potentialsMajor inhibitory roleExcitatory functionGlutamate responseGlutamate receptorsKainate receptorsMammalian CNSMaximal effectSlight temporal delayNeuronal circuitsInhibitory roleNeuronsReceptorsBroad time windowDepolarizationGlutamatePresent studySimilar results