2018
Membrane shape-mediated wave propagation of cortical protein dynamics
Wu Z, Su M, Tong C, Wu M, Liu J. Membrane shape-mediated wave propagation of cortical protein dynamics. Nature Communications 2018, 9: 136. PMID: 29321558, PMCID: PMC5762918, DOI: 10.1038/s41467-017-02469-1.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCdc42 GTP-Binding ProteinCell Line, TumorCell MembraneCell ShapeMembrane ProteinsModels, TheoreticalRatsConceptsMembrane shape changesF-BAR proteinsDomain-containing proteinsPeripheral membrane proteinsProtein lateral diffusionActin machineryProtein recruitmentMembrane proteinsProtein dynamicsCortical proteinsShape changesProtein waveActin wavesUnderappreciated roleProteinMembrane undulationsLateral diffusionSpatial gradientsMachineryCytoplasmImmune cellsRecruitmentAssemblyCells
2016
Frequency and amplitude control of cortical oscillations by phosphoinositide waves
Xiong D, Xiao S, Guo S, Lin Q, Nakatsu F, Wu M. Frequency and amplitude control of cortical oscillations by phosphoinositide waves. Nature Chemical Biology 2016, 12: 159-166. PMID: 26751515, DOI: 10.1038/nchembio.2000.Peer-Reviewed Original ResearchActinsAnimalsCell Line, TumorCerebral CortexCytoskeletonInositol Polyphosphate 5-PhosphatasesKineticsLeukemia, Basophilic, AcuteLipid MetabolismMast CellsNerve Tissue ProteinsPhosphatidylinositol 3-KinasesPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol PhosphatesPhosphatidylinositolsPhosphoric Monoester HydrolasesRats
2013
Calcium oscillations-coupled conversion of actin travelling waves to standing oscillations
Wu M, Wu X, De Camilli P. Calcium oscillations-coupled conversion of actin travelling waves to standing oscillations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 1339-1344. PMID: 23297209, PMCID: PMC3557052, DOI: 10.1073/pnas.1221538110.Peer-Reviewed Original ResearchConceptsPlasma membraneActin regulatory proteinsActin cytoskeletonActin dynamicsActive Cdc42Cell cortexCell physiologyRegulatory proteinsActin polymerizationDynamic spatial patternsMacromolecular assembliesCalcium oscillationsSpatial patternsActinMembraneFBP17Cdc42CellsCytoskeletonFeedback mechanismProteinPhysiologyAntigen stimulationGlobal fluctuationsMechanism
2005
High Spatial Resolution Observation of Single-Molecule Dynamics in Living Cell Membranes
Edel J, Wu M, Baird B, Craighead H. High Spatial Resolution Observation of Single-Molecule Dynamics in Living Cell Membranes. Biophysical Journal 2005, 88: l43-l45. PMID: 15821167, PMCID: PMC1305672, DOI: 10.1529/biophysj.105.061937.Peer-Reviewed Original ResearchConceptsZero-mode waveguidesHigh spatial resolution observationsSpatial resolution observationsCell membraneSingle-molecule dynamicsOptical confinementBiological membrane functionResolution observationsCell membrane componentsFluorescent excitationCellular organellesCytosolic poolCellular membranesMembrane componentsSingle moleculesMembrane functionLipid diffusionBiological membranesRat basophilic leukemia cellsLipid bilayersConfocal microscopyConfinementBasophilic leukemia cellsIndividual moleculesEssential building blocks
2004
Visualization of plasma membrane compartmentalization with patterned lipid bilayers
Wu M, Holowka D, Craighead HG, Baird B. Visualization of plasma membrane compartmentalization with patterned lipid bilayers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 13798-13803. PMID: 15356342, PMCID: PMC518836, DOI: 10.1073/pnas.0403835101.Peer-Reviewed Original ResearchConceptsLipid raftsLeaflet componentsPlasma membrane compartmentalizationReceptor clustersMembrane structural organizationLipid bilayersFcepsilon receptor ITyrosine phosphorylation activityMembrane compartmentalizationLyn kinaseInner leafletPhosphorylation activityActin polymerizationCellular componentsStructural organizationCell receptorRaftsCell activationReceptor IMast cell receptorsStructural reorganizationKinaseUnique insightsBilayersProtein