2021
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 2021, 184: 6262-6280.e26. PMID: 34910928, PMCID: PMC8941949, DOI: 10.1016/j.cell.2021.11.031.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAdenomaAdultAgedAnimalsCarcinogenesisCell DeathCell DifferentiationColonic PolypsColorectal NeoplasmsDisease ProgressionFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksGenetic HeterogeneityHumansMaleMiceMiddle AgedMutationNeoplastic Stem CellsReproducibility of ResultsRNA-SeqSingle-Cell AnalysisTumor MicroenvironmentConceptsHuman colorectal polypsColorectal cancerColorectal polypsPrevention of CRCMicrosatellite-unstable colorectal cancersUnstable colorectal cancersGastric metaplasiaImmune microenvironmentTumor cell differentiation statusImmune cellsPrecision surveillancePrecursor polypsSerrated polypsConventional adenomasStem cell propertiesMalignant progressionImmunogenic potentialPolypsTumor cellsTherapeutic insightsCell differentiation statusCellular originMetaplasiaAdenomasMolecular heterogeneity
2020
Key histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria
Liang J, Shi C, Dupont WD, Salaria SN, Huh WJ, Correa H, Roland JT, Perri RE, Washington MK. Key histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria. Modern Pathology 2020, 34: 592-602. PMID: 32958831, DOI: 10.1038/s41379-020-00676-8.Peer-Reviewed Original ResearchConceptsIdiopathic noncirrhotic portal hypertensionObliterative portal venopathyNoncirrhotic portal hypertensionPortal hypertensionLiver biopsyDiagnostic criteriaInterobserver agreement studyHistologic featuresHistopathologic diagnostic criteriaOriginal pathologic diagnosisPractical diagnostic criteriaAgreement studyKey histopathologicPortal venopathyVein sclerosisHistologic predictorsClinicopathologic correlationHistologic diagnosisPathologic diagnosisHistologic assessmentExperienced hepatopathologistsClinical informationHypertensionBiopsyThree-tiered classification
2017
In liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous
Charoenpitakchai M, Liu E, Zhao Z, Koyama T, Huh WJ, Berlin J, Hande K, Walker R, Shi C. In liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous. Virchows Archiv 2017, 470: 545-552. PMID: 28213807, PMCID: PMC5623953, DOI: 10.1007/s00428-017-2093-3.Peer-Reviewed Original ResearchConceptsSmall intestinal neuroendocrine tumorsLiver metastasesSSTR2A expressionIntestinal neuroendocrine tumorsKi67 indexNeuroendocrine tumorsPrimary tumorLiver tumorsMetastatic small intestinal neuroendocrine tumorsMore liver lesionsMost liver tumorsCorresponding liver metastasesMore liver tumorsFormalin-fixed paraffin-embedded sectionsParaffin-embedded sectionsMetastatic lesionsMetastatic tumorsSI-NETsSame patientLiver lesionsIHC scoreMetastasisScoring systemSignificant associationTumor tissue
2016
Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition
Gonzalez RS, Huh WJ, Cates JM, Washington K, Beauchamp RD, Coffey RJ, Shi C. Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition. Histopathology 2016, 70: 223-231. PMID: 27560620, PMCID: PMC5921077, DOI: 10.1111/his.13068.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transitionColorectal carcinomaDistant metastasisImmunohistochemical evidenceEvidence of EMTAdvanced T categoryConventional colorectal carcinomaCystic nodal metastasisStage IV diseaseAdvanced local diseaseLymph node metastasisMicrosatellite instability testingBRAF V600E mutationMedian survivalMucinous featuresOverall survivalNodal metastasisNode metastasisLocal diseaseMicropapillary featuresT categoryDirty necrosisCribriform patternKRAS mutationsProminent necrosisThe Spectrum of Histologic Findings in Hepatic Outflow Obstruction
Gonzalez RS, Gilger MA, Huh WJ, Washington MK. The Spectrum of Histologic Findings in Hepatic Outflow Obstruction. Archives Of Pathology & Laboratory Medicine 2016, 141: 98-103. PMID: 27681331, PMCID: PMC6420777, DOI: 10.5858/arpa.2015-0388-oa.Peer-Reviewed Original ResearchConceptsHepatic outflow obstructionPortal tract changesCardiac hepatopathyBudd-Chiari syndromeOutflow obstructionHistologic findingsBudd-ChiariSinusoidal fibrosisSinusoidal dilationTract changesCentral veinHepatic venous outflow obstructionVenous outflow obstructionBile ductular reactionDistinctive histologic findingsHepatocyte dropoutDifferent pathophysiologyPrior diagnosisChronic inflammationCentrilobular necrosisDuctular reactionMorphologic findingsUndiagnosed patientsChronic natureHepatopathy
2013
Chronic Tamoxifen Use Is Associated with a Decreased Risk of Intestinal Metaplasia in Human Gastric Epithelium
Moon CM, Kim SH, Lee SK, Hyeon J, Koo JS, Lee S, Wang JS, Huh WJ, Khurana SS, Mills JC. Chronic Tamoxifen Use Is Associated with a Decreased Risk of Intestinal Metaplasia in Human Gastric Epithelium. Digestive Diseases And Sciences 2013, 59: 1244-1254. PMID: 24368421, PMCID: PMC4035390, DOI: 10.1007/s10620-013-2994-1.Peer-Reviewed Original ResearchConceptsRisk of IMTamoxifen useEndoscopic gastroduodenoscopyDecreased riskGastric cancerFemale breast cancer patientsMultivariate logistic regression analysisHuman stomachHelicobacter pylori positivityBreast cancer patientsEffect of tamoxifenLogistic regression analysisHuman gastric epitheliumClinical characteristicsPylori positivityHistopathological findingsIntestinal metaplasiaPredictive factorsSydney classificationBreast surgeryCancer patientsGastric biopsiesPremalignant lesionsEstrogen exposureBiopsy site