2014
In Vitro Culture Increases the Frequency of Stochastic Epigenetic Errors at Imprinted Genes in Placental Tissues from Mouse Concepti Produced Through Assisted Reproductive Technologies1
de Waal E, Mak W, Calhoun S, Stein P, Ord T, Krapp C, Coutifaris C, Schultz RM, Bartolomei MS. In Vitro Culture Increases the Frequency of Stochastic Epigenetic Errors at Imprinted Genes in Placental Tissues from Mouse Concepti Produced Through Assisted Reproductive Technologies1. Biology Of Reproduction 2014, 90: 22, 1-12. PMID: 24337315, PMCID: PMC4076403, DOI: 10.1095/biolreprod.113.114785.Peer-Reviewed Original ResearchConceptsEpigenetic errorsEpigenetic defectsART-conceived offspringImprinted genesMammalian embryosDNA methylationEpigenetic profilesPreimplantation developmentEpigenetic abnormalitiesAssisted Reproductive TechnologyMammalian speciesMouse conceptiMouse embryosExpression profilesEmbryonic tissuesAbnormal methylationGenesEmbryosPlacental tissueIVF embryosVitro CultureMethylationHigh oxygen tensionLow birth weightMillions of couples
2013
Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females
McGraw S, Oakes CC, Martel J, Cirio MC, de Zeeuw P, Mak W, Plass C, Bartolomei MS, Chaillet JR, Trasler JM. Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females. PLOS Genetics 2013, 9: e1003873. PMID: 24278026, PMCID: PMC3836718, DOI: 10.1371/journal.pgen.1003873.Peer-Reviewed Original ResearchConceptsImprinted X-chromosome inactivationX-chromosome inactivationChromosome inactivationImprinted X inactivationDNA methylation eventsX-inactivation centerDNA methylation patternsKey regulatory regionsGenomic imprintsMethylation maintenanceGenomic imprintingImprinted lociFemale blastocystsMethylation eventsExtraembryonic tissuesBiallelic expressionMethylation patternsRegulatory regionsPreimplantation developmentAffected lociX chromosomeX inactivationMouse embryosDNA hypomethylationPreimplantation embryos