Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females
McGraw S, Oakes CC, Martel J, Cirio MC, de Zeeuw P, Mak W, Plass C, Bartolomei MS, Chaillet JR, Trasler JM. Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females. PLOS Genetics 2013, 9: e1003873. PMID: 24278026, PMCID: PMC3836718, DOI: 10.1371/journal.pgen.1003873.Peer-Reviewed Original ResearchConceptsImprinted X-chromosome inactivationX-chromosome inactivationChromosome inactivationImprinted X inactivationDNA methylation eventsX-inactivation centerDNA methylation patternsKey regulatory regionsGenomic imprintsMethylation maintenanceGenomic imprintingImprinted lociFemale blastocystsMethylation eventsExtraembryonic tissuesBiallelic expressionMethylation patternsRegulatory regionsPreimplantation developmentAffected lociX chromosomeX inactivationMouse embryosDNA hypomethylationPreimplantation embryos