2014
Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children With Type 1 Diabetes: Association With Hyperglycemia
Mauras N, Mazaika P, Buckingham B, Weinzimer S, White NH, Tsalikian E, Hershey T, Cato A, Cheng P, Kollman C, Beck RW, Ruedy K, Aye T, Fox L, Arbelaez AM, Wilson D, Tansey M, Tamborlane W, Peng D, Marzelli M, Winer KK, Reiss AL. Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children With Type 1 Diabetes: Association With Hyperglycemia. Diabetes 2014, 64: 1770-1779. PMID: 25488901, PMCID: PMC4407847, DOI: 10.2337/db14-1445.Peer-Reviewed Original ResearchConceptsWhite matter growthControl subjectsAge-matched control subjectsType 1 diabetesHigh-resolution structural MRIWhite matter areasWhite matter volumeYoung childrenContinuous glucose monitoringGray matter regionsNondiabetic childrenChronic hyperglycemiaExecutive function scoresFunction scoresGlucose variabilityMatter volumeChildren ages 4Comprehensive neurocognitive testsBrain regionsLongitudinal assessmentType 1Structural MRIHyperglycemiaDiabetesMatter regions
2013
Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
Marzelli MJ, Mazaika PK, Barnea-Goraly N, Hershey T, Tsalikian E, Tamborlane W, Mauras N, White NH, Buckingham B, Beck RW, Ruedy KJ, Kollman C, Cheng P, Reiss AL, Network F. Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes. Diabetes 2013, 63: 343-353. PMID: 24170697, PMCID: PMC3868050, DOI: 10.2337/db13-0179.Peer-Reviewed Original ResearchMeSH KeywordsBlood GlucoseBrainChildChild, PreschoolDiabetes Mellitus, Type 1FemaleHumansIntelligence TestsMagnetic Resonance ImagingMaleOrgan SizeConceptsGray matter volumeT1D groupControl subjectsWhole brain volumetric analysisAge-matched control subjectsEarly-onset T1DNeuroanatomical correlatesType 1 diabetesRegional brain volumesYoung childrenVoxel-based morphometryMedial prefrontal cortexGlycemic dysregulationGlycemic exposureTemporal-occipital regionsTemporal pole regionsStructural magnetic resonance imagesHyperglycemic exposureMatter volumeBrain volumeType 1Cerebellar regionsPrefrontal cortexBrain structuresMagnetic resonance images