2013
Blunted glucagon but not epinephrine responses to hypoglycemia occurs in youth with less than 1 yr duration of type 1 diabetes mellitus
Arbelaez AM, Xing D, Cryer PE, Kollman C, Beck RW, Sherr J, Ruedy KJ, Tamborlane WV, Mauras N, Tsalikian E, Wilson DM, White NH, Group F. Blunted glucagon but not epinephrine responses to hypoglycemia occurs in youth with less than 1 yr duration of type 1 diabetes mellitus. Pediatric Diabetes 2013, 15: 127-134. PMID: 23992543, PMCID: PMC3858506, DOI: 10.1111/pedi.12070.Peer-Reviewed Original ResearchConceptsType 1 diabetes mellitusPeak epinephrineEpinephrine responseDiabetes mellitusT1DM subjectsRecent-onset type 1 diabetes mellitusHypoglycemia-associated autonomic failureBarrier of hypoglycemiaInsulin-induced hypoglycemiaAutonomic failureCounterregulatory hormonesSubsequent hypoglycemiaGlucagon responsePatients 9Recurrent hypoglycemiaGlycemic controlHypoglycemic clampEpinephrine levelsHypoglycemiaHormonal responsesT1DMGlucagonMellitusControl 19CR response
2006
Effects of hypoglycemia on human brain activation measured with fMRI
Anderson AW, Heptulla RA, Driesen N, Flanagan D, Goldberg PA, Jones TW, Rife F, Sarofin H, Tamborlane W, Sherwin R, Gore JC. Effects of hypoglycemia on human brain activation measured with fMRI. Magnetic Resonance Imaging 2006, 24: 693-697. PMID: 16824963, DOI: 10.1016/j.mri.2006.03.013.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingBrain activationHuman brain activationPassive sensory stimulationCognitive tasksFMRI activityVisual stimuliEuglycemic clamp studiesBlood glucose levelsLevel-dependent contrastEffects of hypoglycemiaBOLD signalSensory stimulationHealthy human subjectsVisual stimulationMagnetic resonance imagingHyperinsulinemic hypoglycemicHealthy brainAcute hypoglycemiaGlucose levelsClamp studiesResonance imagingFractional signal changeHypoglycemiaEuglycemia
2003
Defective Activation of Skeletal Muscle and Adipose Tissue Lipolysis in Type 1 Diabetes Mellitus during Hypoglycemia
Enoksson S, Caprio SK, Rife F, Shulman GI, Tamborlane WV, Sherwin RS. Defective Activation of Skeletal Muscle and Adipose Tissue Lipolysis in Type 1 Diabetes Mellitus during Hypoglycemia. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 1503-1511. PMID: 12679430, DOI: 10.1210/jc.2002-021013.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdrenergic beta-AgonistsAdultBlood GlucoseDiabetes Mellitus, Type 1EpinephrineFatty Acids, NonesterifiedFemaleGlucoseGlucose Clamp TechniqueGlycerolHomeostasisHumansHypoglycemiaInsulinLactic AcidLipolysisMaleMuscle, SkeletalNorepinephrineReceptors, Adrenergic, beta-2TerbutalineConceptsT1DM patientsControl subjectsGlucose disposalAdipose tissueType 1 diabetes mellitus patientsWhole-body glucose disposalWhole-body glucose useSkeletal muscleDiabetes mellitus patientsGlucagon secretory responsesRisk of hypoglycemiaPlasma epinephrine concentrationSeverity of hypoglycemiaAdipose tissue lipolysisMajor target tissuesHyperinsulinemic euglycemiaAgonist terbutalineAdrenomedullary responseMellitus patientsNondiabetic subjectsDeficient releasePlasma epinephrinePlasma glucoseInsulin infusionCatecholamine secretionLocal Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation
Borg MA, Tamborlane WV, Shulman GI, Sherwin RS. Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation. Diabetes 2003, 52: 663-666. PMID: 12606506, DOI: 10.2337/diabetes.52.3.663.Peer-Reviewed Original ResearchConceptsCounterregulatory hormone responsesVentromedial hypothalamusHormone responseSprague-Dawley ratsGlucose-sensing mechanismHypoglycemic counterregulationSystemic hypoglycemiaHormonal suppressionLactate perfusionApproximate fourfold increaseGlucose metabolismMicrodialysis perfusionGlucose perfusionHormonal responsesHypoglycemic plateauHypoglycemiaPerfusionL-lactateExogenous glucoseFourfold increaseGlucoseLactate
1999
Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats.
Borg MA, Borg WP, Tamborlane WV, Brines ML, Shulman GI, Sherwin RS. Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats. Diabetes 1999, 48: 584-587. PMID: 10078560, DOI: 10.2337/diabetes.48.3.584.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamusSystemic hypoglycemiaChronic hypoglycemiaCellular glucopeniaDefective counterregulationDiabetic BBNondiabetic BBDiabetic groupEpinephrine responseNorepinephrine responseCatecholamine responsesIatrogenic hypoglycemiaDiabetic ratsGlucagon releaseEfferent pathwaysSympathoadrenal systemControl ratsHypoglycemic ratsHypoglycemiaGlucopeniaCounterregulationRatsHypothalamusPerfusionCritical role
1997
Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.
Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. Journal Of Clinical Investigation 1997, 99: 361-365. PMID: 9006005, PMCID: PMC507804, DOI: 10.1172/jci119165.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamic nucleusMM D-glucoseControl groupGlucose perfusionHypoglycemic counterregulationSystemic hypoglycemiaNorepinephrine releaseGlucagon secretionCatecholamine concentrationsHypothalamic nucleiAwake ratsHormonal secretionControl animalsHypoglycemiaHormonal responsesPerfusionL glucoseCounterregulationD-glucoseGlucagonRatsSecretionGlucoseAnimalsGlucopenia
1993
Effect of insulin-like growth factor-1 on the responses to and recognition of hypoglycemia in humans. A comparison with insulin.
Kerr D, Tamborlane WV, Rife F, Sherwin RS. Effect of insulin-like growth factor-1 on the responses to and recognition of hypoglycemia in humans. A comparison with insulin. Journal Of Clinical Investigation 1993, 91: 141-147. PMID: 8423214, PMCID: PMC330007, DOI: 10.1172/jci116163.Peer-Reviewed Original ResearchConceptsRecombinant human insulin-like growth factor-1Insulin-like growth factor-1Growth factor-1Glucagon responseGlucose productionAbsent glucagon responsesPlasma glucose nadirsGrowth hormone responseInsulin-induced hypoglycemiaAwareness of hypoglycemiaGrowth hormone releaseFactor 1Hepatic glucose productionHuman insulin-like growth factor-1Recognition of hypoglycemiaSymptomatic awarenessNorepinephrine levelsCounterregulatory responsesHypoglycemic stimulusSympathetic activityGlucose nadirsGlucagon releaseBlood glucoseRebound increaseHormone release
1992
Impaired stimulation of gluconeogenesis during prolonged hypoglycemia in intensively treated insulin-dependent diabetic subjects
Caprio S, Napoli R, Saccà L, Tamborlane WV, Sherwin RS. Impaired stimulation of gluconeogenesis during prolonged hypoglycemia in intensively treated insulin-dependent diabetic subjects. The Journal Of Clinical Endocrinology & Metabolism 1992, 75: 1076-1080. PMID: 1400874, DOI: 10.1210/jcem.75.4.1400874.Peer-Reviewed Original ResearchConceptsType I diabetic subjectsHepatic glucose productionDiabetic subjectsGlucose productionControl subjectsInsulin-dependent diabetic subjectsDefective glucose counterregulationFailure of gluconeogenesisLow-dose infusionInsulin-induced hypoglycemiaInsulin-dependent diabetesNormal control subjectsGlucagon responseGlucose counterregulationIDDM patientsIDDM subjectsDose infusionEpinephrine releaseInsulin levelsPlasma glucoseImpaired stimulationConversion of alanineNormal subjectsCompensatory stimulationHepatic response
1991
SUPPRESSION OF COUNTERREGULATORY HORMONE RESPONSE TO HYPOGLYCEMIA BY INSULIN PER SE
DIAMOND M, HALLARMAN L, STARICK-ZYCH K, JONES T, CONNOLLY-HOWARD M, TAMBORLANE W, SHERWIN R. SUPPRESSION OF COUNTERREGULATORY HORMONE RESPONSE TO HYPOGLYCEMIA BY INSULIN PER SE. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 1388-1390. PMID: 2026760, DOI: 10.1210/jcem-72-6-1388.Peer-Reviewed Original ResearchConceptsCounterregulatory hormone responsesHormone responseGlucose levelsNormal subjectsCounterregulatory hormone levelsResponses of epinephrineVariable glucose infusionDegree of hyperinsulinemiaHigh-dose studiesHypoglycemic clamp studiesHypoglycemic counterregulationHypoglycemic stimulusInsulin doseExogenous insulinDose studyHormone levelsGlucose infusionClamp studiesHypoglycemiaGrowth hormoneHypoglycemic plateauInsulinModulating effectOnly variableHyperinsulinemiaOpiate blockade enhances hypoglycemic counterregulation in normal and insulin-dependent diabetic subjects
Caprio S, Gerety G, Tamborlane WV, Jones T, Diamond M, Jacob R, Sherwin RS. Opiate blockade enhances hypoglycemic counterregulation in normal and insulin-dependent diabetic subjects. American Journal Of Physiology 1991, 260: e852-e858. PMID: 2058661, DOI: 10.1152/ajpendo.1991.260.6.e852.Peer-Reviewed Original ResearchConceptsInsulin-induced hypoglycemiaGlucose counterregulationIDDM patientsGlucose productionOpiate blockadeHormonal responsesInsulin-dependent diabetic subjectsCounterregulatory hormone releaseDefective glucose counterregulationInsulin clamp studiesAbsence of hypoglycemiaInsulin-dependent patientsVariable glucose infusionDefective counterregulationHypoglycemic counterregulationNaloxone studyGlucagon responseDiabetic subjectsEndogenous opiatesGlucoregulatory hormonesGlucoregulatory responsesHormone releaseGlucose infusionHealthy subjectsCortisol release
1985
Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type I diabetes.
Simonson DC, Tamborlane WV, DeFronzo RA, Sherwin RS. Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type I diabetes. Annals Of Internal Medicine 1985, 103: 184-90. PMID: 3893253, DOI: 10.7326/0003-4819-103-2-184.Peer-Reviewed Original ResearchConceptsCounterregulatory hormone responsesPump treatmentHormone responseCounterregulatory hormone releaseInsulin pump treatmentPerception of hypoglycemiaIntensive insulin therapyIntensive insulin treatmentInsulin clamp techniqueType IBlood glucose levelsCounterregulatory hormonesGlucose counterregulationInsulin therapyHypoglycemic stimulusHypoglycemic episodesGlucagon releaseHealthy controlsInsulin treatmentHormone releaseStudy groupGlucose levelsHypoglycemic periodNormal controlsHypoglycemia
1983
Effect of growth hormone on oral glucose tolerance and circulating metabolic fuels in man
Sherwin RS, Schulman GA, Hendler R, Walesky M, Belous A, Tamborlane W. Effect of growth hormone on oral glucose tolerance and circulating metabolic fuels in man. Diabetologia 1983, 24: 155-161. PMID: 6341144, DOI: 10.1007/bf00250154.Peer-Reviewed Original ResearchConceptsGrowth hormone excessNon-esterified fatty acidsGrowth hormoneHormone excessHigher plasma insulin concentrationsOral glucose toleranceInsulin antagonistic effectsGrowth hormone infusionHigher insulin levelsInfusion of cortisolPlasma insulin concentrationOral glucoseGlucose intoleranceGlucose toleranceSomatomedin concentrationsInsulin levelsFatty acidsHormone infusionPlasma glucoseHyperglycaemic responseInsulin concentrationsNormal suppressionGlucose curveGlucose levelsNormal subjects