1992
Impaired stimulation of gluconeogenesis during prolonged hypoglycemia in intensively treated insulin-dependent diabetic subjects
Caprio S, Napoli R, Saccà L, Tamborlane WV, Sherwin RS. Impaired stimulation of gluconeogenesis during prolonged hypoglycemia in intensively treated insulin-dependent diabetic subjects. The Journal Of Clinical Endocrinology & Metabolism 1992, 75: 1076-1080. PMID: 1400874, DOI: 10.1210/jcem.75.4.1400874.Peer-Reviewed Original ResearchConceptsType I diabetic subjectsHepatic glucose productionDiabetic subjectsGlucose productionControl subjectsInsulin-dependent diabetic subjectsDefective glucose counterregulationFailure of gluconeogenesisLow-dose infusionInsulin-induced hypoglycemiaInsulin-dependent diabetesNormal control subjectsGlucagon responseGlucose counterregulationIDDM patientsIDDM subjectsDose infusionEpinephrine releaseInsulin levelsPlasma glucoseImpaired stimulationConversion of alanineNormal subjectsCompensatory stimulationHepatic response
1991
SUPPRESSION OF COUNTERREGULATORY HORMONE RESPONSE TO HYPOGLYCEMIA BY INSULIN PER SE
DIAMOND M, HALLARMAN L, STARICK-ZYCH K, JONES T, CONNOLLY-HOWARD M, TAMBORLANE W, SHERWIN R. SUPPRESSION OF COUNTERREGULATORY HORMONE RESPONSE TO HYPOGLYCEMIA BY INSULIN PER SE. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 1388-1390. PMID: 2026760, DOI: 10.1210/jcem-72-6-1388.Peer-Reviewed Original ResearchConceptsCounterregulatory hormone responsesHormone responseGlucose levelsNormal subjectsCounterregulatory hormone levelsResponses of epinephrineVariable glucose infusionDegree of hyperinsulinemiaHigh-dose studiesHypoglycemic clamp studiesHypoglycemic counterregulationHypoglycemic stimulusInsulin doseExogenous insulinDose studyHormone levelsGlucose infusionClamp studiesHypoglycemiaGrowth hormoneHypoglycemic plateauInsulinModulating effectOnly variableHyperinsulinemia
1989
Oxidative fuel metabolism during mild hypoglycemia: critical role of free fatty acids
Caprio S, Gelfand RA, Tamborlane WV, Sherwin RS. Oxidative fuel metabolism during mild hypoglycemia: critical role of free fatty acids. American Journal Of Physiology 1989, 256: e413-e419. PMID: 2646946, DOI: 10.1152/ajpendo.1989.256.3.e413.Peer-Reviewed Original ResearchConceptsFree fatty acidsCarbohydrate oxidationFuel metabolismGlucose uptakeInsulin-induced fallInsulin-induced hypoglycemiaFatty acidsMild hypoglycemiaCatecholamine releaseMild hyperinsulinemiaAddition of heparinNormal subjectsFat oxidationTransient decreaseGlucose productionGroup of studiesHypoglycemiaInsulinPropranololEarly riseHeparinGlucose concentrationBase lineMetabolismLatter changes
1983
Effect of growth hormone on oral glucose tolerance and circulating metabolic fuels in man
Sherwin RS, Schulman GA, Hendler R, Walesky M, Belous A, Tamborlane W. Effect of growth hormone on oral glucose tolerance and circulating metabolic fuels in man. Diabetologia 1983, 24: 155-161. PMID: 6341144, DOI: 10.1007/bf00250154.Peer-Reviewed Original ResearchConceptsGrowth hormone excessNon-esterified fatty acidsGrowth hormoneHormone excessHigher plasma insulin concentrationsOral glucose toleranceInsulin antagonistic effectsGrowth hormone infusionHigher insulin levelsInfusion of cortisolPlasma insulin concentrationOral glucoseGlucose intoleranceGlucose toleranceSomatomedin concentrationsInsulin levelsFatty acidsHormone infusionPlasma glucoseHyperglycaemic responseInsulin concentrationsNormal suppressionGlucose curveGlucose levelsNormal subjects