1994
Effects of puberty and diabetes on metabolism of insulin-sensitive fuels
Caprio S, Cline G, Boulware S, Permanente C, Shulman GI, Sherwin RS, Tamborlane WV. Effects of puberty and diabetes on metabolism of insulin-sensitive fuels. American Journal Of Physiology 1994, 266: e885-e891. PMID: 8023918, DOI: 10.1152/ajpendo.1994.266.6.e885.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusIDDM adolescentsEffect of pubertyGlucose metabolismNondiabetic groupIDDM subjectsInsulin infusionHealthy controlsLeucine fluxHealthy young adult controlsLow-dose insulin infusionPlasma free fatty acid levelsFree fatty acid levelsYoung adult controlsFatty acid levelsAction of insulinLeucine oxidation rateAmino acid/protein metabolismEuglycemic hyperinsulinemiaDiabetes mellitusInsulin resistanceInsulin valuesBasal glucosePlasma insulinNormal puberty
1992
Impaired stimulation of gluconeogenesis during prolonged hypoglycemia in intensively treated insulin-dependent diabetic subjects
Caprio S, Napoli R, Saccà L, Tamborlane WV, Sherwin RS. Impaired stimulation of gluconeogenesis during prolonged hypoglycemia in intensively treated insulin-dependent diabetic subjects. The Journal Of Clinical Endocrinology & Metabolism 1992, 75: 1076-1080. PMID: 1400874, DOI: 10.1210/jcem.75.4.1400874.Peer-Reviewed Original ResearchConceptsType I diabetic subjectsHepatic glucose productionDiabetic subjectsGlucose productionControl subjectsInsulin-dependent diabetic subjectsDefective glucose counterregulationFailure of gluconeogenesisLow-dose infusionInsulin-induced hypoglycemiaInsulin-dependent diabetesNormal control subjectsGlucagon responseGlucose counterregulationIDDM patientsIDDM subjectsDose infusionEpinephrine releaseInsulin levelsPlasma glucoseImpaired stimulationConversion of alanineNormal subjectsCompensatory stimulationHepatic response