1992
Diverse effects of insulin-like growth factor I on glucose, lipid, and amino acid metabolism
Boulware SD, Tamborlane WV, Matthews LS, Sherwin RS. Diverse effects of insulin-like growth factor I on glucose, lipid, and amino acid metabolism. American Journal Of Physiology 1992, 262: e130-e133. PMID: 1733244, DOI: 10.1152/ajpendo.1992.262.1.e130.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor IIGF-I levelsGrowth factor IInsulin secretionTotal IGF-I levelsFree IGF-I levelsAcid metabolismRecombinant human insulin-like growth factor IFactor IAmino acid metabolismFree fatty acid metabolismHealthy nonobese subjectsHuman insulin-like growth factor IHepatic glucose productionBranched-chain amino acidsExogenous glucose infusionFatty acid metabolismGlucagon levelsInsulin levelsNonobese subjectsContinuous infusionConcomitant inhibitory effectTwo- to threefold increaseC-peptideGlucose infusion
1991
Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats
Jacob RJ, Sherwin RS, Bowen L, Fryburg D, Fagin KD, Tamborlane WV, Shulman GI. Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats. American Journal Of Physiology 1991, 260: e262-e268. PMID: 1996629, DOI: 10.1152/ajpendo.1991.260.2.e262.Peer-Reviewed Original ResearchConceptsBB/W ratsBeta-hydroxybutyrate levelsDiabetic ratsNondiabetic ratsGlucose uptakeW ratsDiabetic BB/W ratsGlucose productionInsulin-like growth factor IIGF-I infusionDiabetic BB ratsInsulin-dependent diabetesMetabolic responseGrowth factor IHepatic glucose productionInsulin-stimulated glucose uptakeGlucose production rateBB ratsMetabolic effectsSimilar twofold increaseIGFRatsFactor IInsulinKetone concentrations