2013
Blunted glucagon but not epinephrine responses to hypoglycemia occurs in youth with less than 1 yr duration of type 1 diabetes mellitus
Arbelaez AM, Xing D, Cryer PE, Kollman C, Beck RW, Sherr J, Ruedy KJ, Tamborlane WV, Mauras N, Tsalikian E, Wilson DM, White NH, Group F. Blunted glucagon but not epinephrine responses to hypoglycemia occurs in youth with less than 1 yr duration of type 1 diabetes mellitus. Pediatric Diabetes 2013, 15: 127-134. PMID: 23992543, PMCID: PMC3858506, DOI: 10.1111/pedi.12070.Peer-Reviewed Original ResearchConceptsType 1 diabetes mellitusPeak epinephrineEpinephrine responseDiabetes mellitusT1DM subjectsRecent-onset type 1 diabetes mellitusHypoglycemia-associated autonomic failureBarrier of hypoglycemiaInsulin-induced hypoglycemiaAutonomic failureCounterregulatory hormonesSubsequent hypoglycemiaGlucagon responsePatients 9Recurrent hypoglycemiaGlycemic controlHypoglycemic clampEpinephrine levelsHypoglycemiaHormonal responsesT1DMGlucagonMellitusControl 19CR response
1995
Enhanced adrenomedullary response and increased susceptibility to neuroglycopenia: Mechanisms underlying the adverse effects of sugar ingestion in healthy children
Jones TW, Borg WP, Boulware SD, McCarthy G, Sherwin RS, Tamborlane WV. Enhanced adrenomedullary response and increased susceptibility to neuroglycopenia: Mechanisms underlying the adverse effects of sugar ingestion in healthy children. The Journal Of Pediatrics 1995, 126: 171-177. PMID: 7844661, DOI: 10.1016/s0022-3476(95)70541-4.Peer-Reviewed Original ResearchConceptsClinical Research CenterHealthy childrenPlasma glucose concentrationAdrenomedullary responseHypoglycemic clampSymptom scoresSugar ingestionStandard oral glucose loadOral glucose loadPlasma epinephrine levelsPlasma glucose levelsGlucose concentrationCognitive effectsSugar-free drinksP300 potentialEpinephrine levelsP300 auditoryGlucose loadInsulin levelsSymptomatic responsePlasma glucoseOral administrationGlucose levelsHormone concentrationsPhysiologic mechanisms