2007
Degree of Obesity and Glucose Allostasis Are Major Effectors of Glucose Tolerance Dynamics in Obese Youth
Weiss R, Cali AM, Dziura J, Burgert TS, Tamborlane WV, Caprio S. Degree of Obesity and Glucose Allostasis Are Major Effectors of Glucose Tolerance Dynamics in Obese Youth. Diabetes Care 2007, 30: 1845-1850. PMID: 17475938, DOI: 10.2337/dc07-0325.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testDegree of obesityElevated glucose levelsObese youthGlucose toleranceAmbient glycemiaInsulin sensitivityGlucose levelsSecond oral glucose tolerance testBaseline BMI z-scoreGlucose tolerance testBMI z-scoreAltered glucose metabolismCross-sectional analysisTolerance testInsulin sensitizationGlucose metabolismObesityZ-scoreLongitudinal assessmentLongitudinal changesMajor effectorGlycemiaSignificant reduction
2003
Quality of Life in School-Aged Children With Type 1 Diabetes on Intensive Treatment and Their Parents
Whittemore R, Urban AD, Tamborlane WV, Grey M. Quality of Life in School-Aged Children With Type 1 Diabetes on Intensive Treatment and Their Parents. The Science Of Diabetes Self-Management And Care 2003, 29: 847-854. PMID: 14603873, DOI: 10.1177/014572170302900514.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultChildCritical CareCross-Sectional StudiesDepressive DisorderDiabetes Mellitus, Type 1Family HealthFemaleHumansInsulin Infusion SystemsMaleMultivariate AnalysisParentsPsychology, ChildQuality of LifeRegression AnalysisSocial SupportSurveys and QuestionnairesTreatment OutcomeConceptsType 1 diabetesQuality of lifeSchool-aged childrenIntensive treatmentMetabolic controlGood metabolic controlComplex chronic illnessDemands of treatmentCross-sectional analysisMost school-age childrenFamily psychosocial variablesChronic illnessIntensive psychosocial supportDepressive symptomsPsychosocial supportDiabetesChildren's qualityPsychosocial variablesChildrenTreatmentFamily factorsParentsSymptomsIllness
1996
Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children
Caprio S, Bronson M, Sherwin RS, Rife F, Tamborlane WV. Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children. Diabetologia 1996, 39: 1489-1497. PMID: 8960831, DOI: 10.1007/s001250050603.Peer-Reviewed Original ResearchConceptsObese groupHyperglycaemic clampInsulin resistanceObese preadolescentsInsulin actionGlucose-stimulated insulin levelsHigher insulin infusion ratesNon-oxidative glucose metabolismGlucose uptakeDuration of obesityGroup of obeseNon-obese subjectsBeta-cell functionDevelopment of obesityEuglycaemic hyperinsulinaemic clampSevere insulin resistanceInsulin infusion rateCross-sectional analysisOnset of pubertyAbility of insulinSevere obesityObese adultsObese childrenObese subjectsInsulin levels