2021
Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia
Park H, Furtado J, Poulet M, Chung M, Yun S, Lee S, Sessa WC, Franco CA, Schwartz MA, Eichmann A. Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation 2021, 144: 805-822. PMID: 34182767, PMCID: PMC8429266, DOI: 10.1161/circulationaha.120.053047.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArteriovenous MalformationsCell MovementEndothelial CellsHumansMiceTelangiectasia, Hereditary HemorrhagicVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2Vascular MalformationsConceptsActivin receptor-like kinase 1Hereditary hemorrhagic telangiectasiaHemorrhagic telangiectasiaVascular malformationsArteriovenous malformationsBlood flowGrowth factor receptor 2Endothelial growth factor receptor 2Vascular endothelial growth factor receptor 2Factor receptor 2Receptor-like kinase 1New potential targetsYAP/TAZ nuclear translocationDeficient miceTransmembrane serine-threonine kinase receptorsDevastating disorderAlk1 deletionReceptor 2Pharmacologic inhibitionCre linesPostnatal retinaMalformationsSerine-threonine kinase receptorsEndothelial cell migrationNuclear translocation
2004
Antiangiogenic therapy Creating a unique “window” of opportunity
Lin M, Sessa W. Antiangiogenic therapy Creating a unique “window” of opportunity. Cancer Cell 2004, 6: 529-531. PMID: 15607955, DOI: 10.1016/j.ccr.2004.12.003.Peer-Reviewed Original ResearchAngiogenesis InhibitorsAngiopoietin-1AnimalsAntibodies, MonoclonalBasement MembraneBlood VesselsCell MovementCollagenasesCombined Modality TherapyGamma RaysGliomaHumansMiceModels, BiologicalNeoplasmsNeovascularization, PathologicPericytesReceptor, TIE-2Time FactorsVascular Endothelial Growth Factor Receptor-2Xenograft Model Antitumor Assays