2013
Enhanced Fasting Glucose Turnover in Mice with Disrupted Action of TUG Protein in Skeletal Muscle*
Löffler MG, Birkenfeld AL, Philbrick KM, Belman JP, Habtemichael EN, Booth CJ, Castorena CM, Choi CS, Jornayvaz FR, Gassaway BM, Lee HY, Cartee GD, Philbrick W, Shulman GI, Samuel VT, Bogan JS. Enhanced Fasting Glucose Turnover in Mice with Disrupted Action of TUG Protein in Skeletal Muscle*. Journal Of Biological Chemistry 2013, 288: 20135-20150. PMID: 23744065, PMCID: PMC3711282, DOI: 10.1074/jbc.m113.458075.Peer-Reviewed Original ResearchMeSH Keywords3T3-L1 CellsAdaptor Proteins, Signal TransducingAnimalsBlood GlucoseCarbon DioxideCarrier ProteinsDeoxyglucoseFastingFemaleGlucoseGlucose Transporter Type 4GlycogenGolgi Matrix ProteinsHypoglycemic AgentsImmunoblottingInsulinIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLMice, Inbred StrainsMice, TransgenicMuscle, SkeletalOxygen ConsumptionProtein TransportProteolysisConceptsGLUT4 translocationGLUT4 glucose transportersMuscle-specific transgenic expressionTransgenic miceT-tubule fractionTUG ProteinInsulin signalSystemic glucose homeostasisDiet-induced insulin resistanceHigh-fat diet-induced insulin resistanceEndoproteolytic cleavageTransgenic expressionTransgenic muscleGlucose transporterCell surfaceEnergy metabolismProteolysisTranslocationGLUT4Skeletal muscleGlucose uptakeHyperinsulinemic clamp studiesExpressionMetabolic rateTurnover
2000
Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia*
Garcia-Ocaña A, Takane K, Syed M, Philbrick W, Vasavada R, Stewart A. Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia*. Journal Of Biological Chemistry 2000, 275: 1226-1232. PMID: 10625667, DOI: 10.1074/jbc.275.2.1226.Peer-Reviewed Original ResearchConceptsHepatocyte growth factorRat insulin II promoterBeta-cell proliferationDiabetogenic effectMild hypoglycemiaIslet massInsulin contentOverexpression of HGFIslet numberInsulin productionBeta-cell replication rateRole of HGFHepatocyte growth factor overexpressionProliferation of isletsBeta-cell massCell proliferationGrowth factor overexpressionMesenchyme-derived cellsPancreatic areaCell replication ratesFasting statesNormal littermatesTransgenic miceHGF mRNAIslet cells