2023
Clear cell chondrosarcoma: a review of clinicopathologic characteristics, differential diagnoses, and patient management
Alexiev B, Vormittag-Nocito E, Peabody T, Samet J, Laskin W. Clear cell chondrosarcoma: a review of clinicopathologic characteristics, differential diagnoses, and patient management. Human Pathology 2023, 139: 126-134. PMID: 37805864, DOI: 10.1016/j.humpath.2023.06.004.Peer-Reviewed Original ResearchConceptsClear cell chondrosarcomaDiagnosis of clear cell chondrosarcomaPrimary bone tumorsDiagnostic accuracy of core needle biopsyAccuracy of core needle biopsyBone tumorsRarest primary bone tumorsLocal recurrence rateAbundant clear cytoplasmCore needle biopsyRate of recurrenceYounger patient ageLow-grade chondrosarcomaSkeletally immature patientsMalignant cartilaginous neoplasmsDecades of lifeEpiphysis of long bonesLow diagnostic accuracyOperative resectionIncomplete excisionNeedle biopsyHistopathological diagnosisPatient ageRecurrence rateClinicopathological characteristics
2011
NUT midline carcinoma: a neoplasm with diagnostic challenges in cytology
Zhu B, Laskin W, Chen Y, French C, Cameron M, Nayar R, Lin X. NUT midline carcinoma: a neoplasm with diagnostic challenges in cytology. Cytopathology 2011, 22: 414-417. PMID: 21210877, DOI: 10.1111/j.1365-2303.2010.00838.x.Peer-Reviewed Original Research
2001
Superficial acral fibromyxoma: A clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes
Fetsch J, Laskin W, Miettinen M. Superficial acral fibromyxoma: A clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes. Human Pathology 2001, 32: 704-714. PMID: 11486169, DOI: 10.1053/hupa.2001.25903.Peer-Reviewed Original ResearchConceptsSoft tissue tumorsDistinctive soft tissue tumorLocal excisionTissue tumorsAcral myxoinflammatory fibroblastic sarcomaFascicular growth patternEpithelial membrane antigenMild nuclear atypiaMyxoinflammatory fibroblastic sarcomaStellate-shaped cellsProgressive diseaseClinicopathologic featuresHMB-45Surgical interventionImmunohistochemical findingsResection specimensSurgical specimensFibrous histiocytomaPartial excisionDifferential diagnosisLesional cellsStudy groupMast cellsNuclear atypiaImmunohistochemical analysisFollicular dendritic cell tumor presenting in the lung: A case report
Shah R, Ozden O, Yeldandi A, Peterson L, Rao S, Laskin W. Follicular dendritic cell tumor presenting in the lung: A case report. Human Pathology 2001, 32: 745-749. PMID: 11486174, DOI: 10.1053/hupa.2001.25595.Peer-Reviewed Original ResearchConceptsFollicular dendritic cell sarcomaEpstein-Barr virusExtranodal follicular dendritic cell sarcomaTumor cellsLow-affinity nerve growth factor receptorDendritic cell sarcomaHilar lymph nodesChronic inflammatory cellsBronchial biopsy specimensComplement receptor CD21Nerve growth factor receptorMuscle-specific actinGrowth factor receptorLymph nodesTumor PresentingCell sarcomaInflammatory cellsCase reportBiopsy specimensPolymerase chain reactionImmunohistochemical panelPleural nodulesDifferential diagnosisPlasma cellsSpindled cellsSolitary fibrous tumor of the prostate a report of 2 cases and review of the literature.
Pins M, Campbell S, Laskin W, Steinbronn K, Dalton D. Solitary fibrous tumor of the prostate a report of 2 cases and review of the literature. Archives Of Pathology & Laboratory Medicine 2001, 125: 274-7. PMID: 11175651, DOI: 10.5858/2001-125-0274-sftotp.Peer-Reviewed Original Research
2000
A Clinicopathologic Study of 45 Pediatric Soft Tissue Tumors With an Admixture of Adipose Tissue and Fibroblastic Elements, and a Proposal for Classification as Lipofibromatosis
Fetsch J, Miettinen M, Laskin W, Michal M, Enzinger F. A Clinicopathologic Study of 45 Pediatric Soft Tissue Tumors With an Admixture of Adipose Tissue and Fibroblastic Elements, and a Proposal for Classification as Lipofibromatosis. The American Journal Of Surgical Pathology 2000, 24: 1491-1500. PMID: 11075850, DOI: 10.1097/00000478-200011000-00004.Peer-Reviewed Original ResearchConceptsPersistent diseaseJuvenile fibromatosisFibroblastic elementsAdipose tissueMuscle actinFibrous hamartomaAlpha-smooth muscle actinPediatric Soft TissueSkeletal muscleMitotic activityRare pediatric neoplasmSoft tissue massAbundant adipose tissueUnivacuolated cellsClinicopathologic studyInitial biopsyClinicopathologic featuresMale sexFascicular growthFocal immunoreactivityIncomplete excisionArchitectural effacementSkin adnexaCytologic atypiaPediatric neoplasmsThe “neurothekeoma”: Immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics
Laskin W, Fetsch J, Miettinen M. The “neurothekeoma”: Immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics. Human Pathology 2000, 31: 1230-1241. PMID: 11070116, DOI: 10.1053/hupa.2000.18474.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinNerve sheath myxomaSpindled cellsPeak incidenceFemale ratioLow-affinity nerve growth factor receptorDense collagenAlpha-smooth muscle actinAnti-neurofilament proteinSoft Tissue RegistryNerve sheath tumorsNerve growth factor receptorDecades of lifeEpithelial membrane antigenFibrillary acidic proteinCollagen type IV expressionGrowth factor receptorSheath tumorsAnatomic distributionLeu-7Consistent immunoreactivityMyxoid variantTissue RegistryImmunohistochemical analysisEpithelioid cells
1999
Nuchal fibrocartilaginous pseudotumor: a clinicopathologic study of five cases and review of the literature.
Laskin W, Fetsch J, Miettinen M. Nuchal fibrocartilaginous pseudotumor: a clinicopathologic study of five cases and review of the literature. Modern Pathology 1999, 12: 663-8. PMID: 10430269.Peer-Reviewed Original ResearchConceptsNuchal fibrocartilaginous pseudotumorEnglish-language medical literatureVague neck painEvidence of recurrentSoft tissueHistory of headComplete local excisionNuchal ligamentDeep soft tissuesChronic mechanical stressLower cervical vertebraeNeck painClinicopathologic studyPersistent diseaseLocal excisionNeck traumaNodular proliferationSimple excisionFibrocartilaginous massCytologic atypiaPosterior aspectNodular massBenign lesionsFibrocartilaginous metaplasiaMedical literature
1998
Angiomyofibroblastomalike Tumor of the Male Genital Tract
Laskin W, Fetsch J, Mostofi F. Angiomyofibroblastomalike Tumor of the Male Genital Tract. The American Journal Of Surgical Pathology 1998, 22: 6-16. PMID: 9422311, DOI: 10.1097/00000478-199801000-00002.Peer-Reviewed Original ResearchConceptsMale genital tractSpindle cell lipomaClinicopathologic featuresGenital tractCell lipomaRecurrent/persistent diseaseGenital tract tumorsProgesterone receptor proteinMuscle-specific actinMedium-sized vesselsMild nuclear atypiaSoft tissue neoplasmSmooth muscle actinEstrogen receptor proteinReceptor proteinPersistent diseaseTract tumorsAbnormal mitotic figuresFocal findingsSimple excisionIntralesional fatSpindled cellsCollagenous stromaInguinal regionNuclear atypia
1997
Superficial Angiomyxoma (Cutaneous Myxoma) A Clinicopathologic Study of 17 Cases Arising in the Genital Region
Fetsch J, Laskin W, Tavassoli F. Superficial Angiomyxoma (Cutaneous Myxoma) A Clinicopathologic Study of 17 Cases Arising in the Genital Region. International Journal Of Gynecological Pathology 1997, 16: 325-334. PMID: 9421071, DOI: 10.1097/00004347-199710000-00006.Peer-Reviewed Original ResearchConceptsSuperficial angiomyxomaGenital regionGlial fibrillary acidic proteinSite of involvementMuscle-specific actinFibrillary acidic proteinSmooth muscle actinYears 11 monthsMedian followClinicopathologic studyMale patientsAntigen modulationProgesterone receptorFibroblast-like cellsPainless massLabium majusEstrogen receptorMedical attentionPatientsMuscle actinS100 proteinCarney complexAcidic proteinMons pubisAngiomyxomaAn intra-abdominal small round cell neoplasm with features of primitive neuroectodermal and desmoplastic round cell tumor and a EWS/FLI-1 fusion transcript
Katz R, Quezado M, Senderowicz A, Villalba L, Laskin W, Tsokos M. An intra-abdominal small round cell neoplasm with features of primitive neuroectodermal and desmoplastic round cell tumor and a EWS/FLI-1 fusion transcript. Human Pathology 1997, 28: 502-509. PMID: 9104953, DOI: 10.1016/s0046-8177(97)90042-3.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAdultBiomarkersBlotting, WesternCarcinoma, Small CellDesminDNA-Binding ProteinsFatal OutcomeHumansImmunohistochemistryKeratinsMaleMicroscopy, ElectronNeuroectodermal Tumors, PrimitiveOncogene Proteins, FusionPolymerase Chain ReactionProto-Oncogene Protein c-fli-1Proto-Oncogene ProteinsSarcoma, EwingTomography, X-Ray ComputedTrans-ActivatorsConceptsDesmoplastic round cell tumorPeripheral primitive neuroectodermal tumorRound cell tumorCell tumorsSmall round cell neoplasmsPNET/Ewing's sarcomaEWS/FLIHybrid tumorsRound cell neoplasmsPrimitive neuroectodermal tumorFusion transcriptsTranscription-polymerase chain reactionNeuroectodermal tumorPolymerase chain reactionCell neoplasmsEwing's sarcomaImmunophenotypic profilePeritoneal cavityCommon histogenesisElectron microscopic appearanceTumorsUnique caseYoung malesMicroscopic appearanceMIC2 protein
1996
Transitional cell carcinoma of the kidney with tumor thrombus into the vena cava
Williams J, Frazier H, Gawith K, Laskin W, Christenson P. Transitional cell carcinoma of the kidney with tumor thrombus into the vena cava. Urology 1996, 48: 932-935. PMID: 8973682, DOI: 10.1016/s0090-4295(96)00312-3.Peer-Reviewed Original ResearchConceptsTransitional cell carcinomaTumor thrombusCell carcinomaPreoperative diagnosisVena cavaAppropriate nonoperative managementUpper urinary tractCorrect preoperative diagnosisShorter postoperative survivalRenal cell carcinomaNonoperative managementPostoperative survivalComplete resectionRadical nephrectomyInferior venaUrinary tractUnusual entityOverall outcomePreoperative planningThrombusCarcinomaVessel wallPrevious casesCavaDiagnosis
1995
Malignant Lymphoma of Soft Tissue in an HIV-1+ Patient: A Rare Site for Primary Malignant Lymphoma with Implications for Treatment
Smith K, Skelton H, Ruiz N, Laskin W, Wagner K. Malignant Lymphoma of Soft Tissue in an HIV-1+ Patient: A Rare Site for Primary Malignant Lymphoma with Implications for Treatment. American Journal Of Dermatopathology 1995, 17: 403-406. PMID: 8600808, DOI: 10.1097/00000372-199508000-00018.Peer-Reviewed Original ResearchConceptsSoft tissue lymphomaHIV-1 diseaseTissue lymphomaLocal therapyMalignant lymphomaSoft tissueHigh-grade soft tissueHIV-1-positive patientsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Complete systemic evaluationEvidence of tumorPrimary malignant lymphomaHigh-grade lesionsFatal opportunistic infectionLarge reported seriesVirus type 1Extranodal lymphomaBetter prognosisOpportunistic infectionsSurgical excisionHodgkin's lymphomaReported seriesHIV-1General populationDesmoplastic malignant melanoma
Skelton H, Smith K, Laskin W, McCarthy W, Gagnier J, Graham J, Lupton G. Desmoplastic malignant melanoma. Journal Of The American Academy Of Dermatology 1995, 32: 717-725. PMID: 7722014, DOI: 10.1016/0190-9622(95)91448-x.Peer-Reviewed Original ResearchConceptsDisease-free survival ratesDesmoplastic malignant melanomaMalignant melanomaSurvival rateHistologic featuresCases of DMMOverall histologic featuresDisease-free survivalArmed Forces InstituteBetter prognosisHMB-45Histologic findingsImmunohistochemical evaluationTumor locationImmunohistochemical studyTumor depthUncommon variantBiologic potentialStromal mucinAdequate materialMelanomaTumorsRelative rarityPatientsNeural differentiation
1991
Epithelioid Variant of Malignant Peripheral Nerve Sheath Tumor (Malignant Epithelioid Schwannoma)
Laskin W, Weiss S, Bratthauer G. Epithelioid Variant of Malignant Peripheral Nerve Sheath Tumor (Malignant Epithelioid Schwannoma). The American Journal Of Surgical Pathology 1991, 15: 1136-1145. PMID: 1746681, DOI: 10.1097/00000478-199112000-00004.Peer-Reviewed Original ResearchConceptsNerve sheath tumorsDeep soft tissuesMalignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsSuperficial soft tissuesSheath tumorsSoft tissueBenign nerve sheath tumorsRounded epithelioid cellsClear cell carcinomaNeuron-specific enolaseMelanoma-associated antigensMalignant rhabdoid tumorMajority of casesVague nodulesMetastatic diseaseAsymptomatic massEpithelioid variantCell carcinomaHistologic patternFavorable coursePleomorphic sarcomaEpithelioid patternBiologic behaviorLinear immunoreactivityAnaplastic large cell lymphoma
Foss R, Laskin W, Lombardi D, Morton A, Snyder J. Anaplastic large cell lymphoma. Head & Neck 1991, 13: 545-548. PMID: 1791148, DOI: 10.1002/hed.2880130612.Peer-Reviewed Original Research
1989
Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases.
Kao G, Laskin W, Olsen T. Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases. Modern Pathology 1989, 2: 20-6. PMID: 2493641.Peer-Reviewed Original ResearchConceptsBenign peripheral nerve sheath tumorsRare benign peripheral nerve sheath tumorPeripheral nerve sheath tumorsTumor cellsGlial fibrillary acid proteinSpindle-shaped tumor cellsNerve sheath tumorsNeuron-specific enolasePlexiform growth patternDistinct cytoplasmic bordersSpindle-shaped cellsVon Recklinghausen's neurofibromatosisMedian agePatient ageSheath tumorsPainful nodulesClinicopathologic correlationNerve fibersMyxoid stromaSchwann cellsNodular variantNuclear palisadingGross examinationVerocay bodiesCytoplasmic borders
1988
Postradiation soft tissue sarcomas: An analysis of 53 cases
Laskin W, Silverman T, Enzinger F. Postradiation soft tissue sarcomas: An analysis of 53 cases. Cancer 1988, 62: 2330-2340. PMID: 3179948, DOI: 10.1002/1097-0142(19881201)62:11<2330::aid-cncr2820621113>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsMalignant fibrous histiocytomaLatency periodMegavoltage radiationTime of diagnosisMean radiation doseSoft tissue sarcomasTypes of sarcomasShort latency periodAdministered radiationClinical characteristicsPatient ageSecondary sarcomaClinicopathologic featuresDismal prognosisExtraskeletal osteosarcomaPatient survivalTissue sarcomasMalignant schwannomaOrthovoltage radiationFibrous histiocytomaExtraskeletal chondrosarcomaSex incidenceMalignant processPatientsSarcoma