2013
Multimodal exercises simultaneously stimulating cortical and brainstem pathways after unilateral corticospinal lesion
Harel NY, Yigitkanli K, Fu Y, Cafferty WB, Strittmatter SM. Multimodal exercises simultaneously stimulating cortical and brainstem pathways after unilateral corticospinal lesion. Brain Research 2013, 1538: 17-25. PMID: 24055330, PMCID: PMC3873870, DOI: 10.1016/j.brainres.2013.07.012.Peer-Reviewed Original ResearchConceptsBrainstem pathwaysMultimodal exerciseCorticospinal tractTraining groupContext of injuryCST pathwayAnatomical outcomesCST injuryPostural exercisesCorticospinal lesionsCollateral sproutingCST lesionElectrophysiological assessmentSpinal cordPhysical exerciseGait kinematicsLimb performanceSynaptic strengthLesionsSubcortical circuitsFiber densityMiceInjuryFurther studiesExercise
2011
Myelin associated inhibitors: A link between injury-induced and experience-dependent plasticity
Akbik F, Cafferty WB, Strittmatter SM. Myelin associated inhibitors: A link between injury-induced and experience-dependent plasticity. Experimental Neurology 2011, 235: 43-52. PMID: 21699896, PMCID: PMC3189418, DOI: 10.1016/j.expneurol.2011.06.006.Peer-Reviewed Original ResearchConceptsExperience-dependent plasticityAnatomical rearrangementsNogo-66 receptor 1Spinal cord injuryNeurologic recoveryFunctional recoveryInciting stimulusCNS injuryCord injuryAxonal regenerationAdult CNSInjury studiesAnimal modelsReceptor 1Common receptorPaired-ImmunoglobulinMyelinInhibitorsInjuryAnatomical growthCNSReceptorsWide spectrumExtracellular matrixGrowth inhibitor
2008
Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function
Cafferty WB, Bradbury EJ, Lidierth M, Jones M, Duffy PJ, Pezet S, McMahon SB. Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function. Journal Of Neuroscience 2008, 28: 11998-12009. PMID: 19005065, PMCID: PMC3844838, DOI: 10.1523/jneurosci.3877-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAfferent PathwaysAnimalsChondroitin ABC LyaseChondroitin Sulfate ProteoglycansDisease Models, AnimalMaleNerve RegenerationNeural ConductionNeuronal PlasticityRatsRats, WistarRecovery of FunctionRhizotomySensation DisordersSensory Receptor CellsSpinal CordSpinal Cord InjuriesSpinal Nerve RootsTreatment OutcomeConceptsSpinal cord injuryFunctional restorationSensory functionSpinal sensory functionsPrimary afferent terminalsVivo electrophysiological recordingsIntact spinal circuitsEnzyme chondroitinase ABCIntrinsic growth potentialAfferent terminalsBehavioral recoveryIntraspinal injectionCord injurySensory deficitsSpinal cordSpinal circuitsAdult ratsMature CNSTherapeutic interventionsExperimental therapeuticsElectrophysiological recordingsAxon growthInjuryIntact pathwaysEnhance functionAxonal growth therapeutics: regeneration or sprouting or plasticity?
Cafferty WB, McGee AW, Strittmatter SM. Axonal growth therapeutics: regeneration or sprouting or plasticity? Trends In Neurosciences 2008, 31: 215-220. PMID: 18395807, PMCID: PMC2678051, DOI: 10.1016/j.tins.2008.02.004.Peer-Reviewed Original ResearchConceptsAxonal growthAstroglial scarHigh clinical significanceFunctional recoveryNeurological injuryInciting eventFunctional deficitsSpinal cordClinical significanceAdult brainLoss of functionCell lossInhibitory factorAxonal connectivityAxonal anatomyAxonal extensionMolecular interventionsMyelinScarCordInjuryBrain
2005
Regulation of neuropilin 1 by spinal cord injury in adult rats
Agudo M, Robinson M, Cafferty W, Bradbury EJ, Kilkenny C, Hunt SP, McMahon SB. Regulation of neuropilin 1 by spinal cord injury in adult rats. Molecular And Cellular Neuroscience 2005, 28: 475-484. PMID: 15737738, DOI: 10.1016/j.mcn.2004.10.008.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDorsal hornCord injurySpinal cordAdult ratsAdjacent dorsal root gangliaNeuropilin-1Dorsal root rhizotomyDorsal root gangliaUnilateral rhizotomyMicroglial cellsRoot gangliaSensory projectionsControl animalsRhizotomyWestern blottingBlood vesselsInjuryRT-PCRSuperficial layersCordLesionsRatsSitu hybridizationHorn
2001
Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons
Cafferty W, Gardiner N, Gavazzi I, Powell J, McMahon S, Heath J, Munson J, Cohen J, Thompson S. Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons. Journal Of Neuroscience 2001, 21: 7161-7170. PMID: 11549727, PMCID: PMC6762988, DOI: 10.1523/jneurosci.21-18-07161.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxotomyCalcitonin Gene-Related PeptideCell DivisionCell SurvivalCells, CulturedCytoprotectionFemaleGanglia, SpinalGrowth InhibitorsInjections, SpinalInterleukin-6Leukemia Inhibitory FactorLymphokinesMaleMiceMice, KnockoutNerve FibersNerve RegenerationNeuritesNeurons, AfferentPhenotypeRatsRats, WistarSciatic NerveTibial NerveConceptsLeukemia inhibitory factorLIF-/- miceAdult sensory neuronsSensory neuronsConditioning injuryInhibitory factorPeptidergic sensory neuronsMammalian sensory neuronsIntrinsic growth capacityExogenous leukemia inhibitory factorNerve damageReceptor antagonistNeuronsConditioning responseNeurite outgrowthInjuryGrowth statusVivoNormal regenerationStatusAntagonistGrowth capacityMice