2016
Reorganization of Intact Descending Motor Circuits to Replace Lost Connections After Injury
Fink KL, Cafferty WB. Reorganization of Intact Descending Motor Circuits to Replace Lost Connections After Injury. Neurotherapeutics 2016, 13: 370-381. PMID: 26846379, PMCID: PMC4824020, DOI: 10.1007/s13311-016-0422-x.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCentral nervous systemMotor pathwaysFunctional recoveryMotor functionMotor circuitsIntact circuitsIncomplete spinal cord injuryPartial spinal cord injuryAdult central nervous systemCorticospinal tract lesionsLimited spontaneous recoveryPermanent functional impairmentSpontaneous functional recoveryExperimental rodent modelsIntrinsic growth capacityRestoration of functionFine motor behaviorRaphespinal tractsDenervated sideTract lesionsCord injuryRubrospinal tractReticulospinal tractCNS neurons
2012
Myelin-derived ephrinB3 restricts axonal regeneration and recovery after adult CNS injury
Duffy P, Wang X, Siegel CS, Tu N, Henkemeyer M, Cafferty WB, Strittmatter SM. Myelin-derived ephrinB3 restricts axonal regeneration and recovery after adult CNS injury. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 5063-5068. PMID: 22411787, PMCID: PMC3323955, DOI: 10.1073/pnas.1113953109.Peer-Reviewed Original ResearchConceptsAxonal regenerationAxonal growthAdult mammalian central nervous systemAdult CNS injuryDorsal hemisection injurySpinal cord injuryMammalian central nervous systemWild-type miceCentral nervous systemCaudal spinal cordAxonal guidance cuesAxonal growth inhibitionLater time pointsGreater spasticityCNS traumaHemisection injuryCrush siteOptic nerveNeurological functionCNS injuryCord injuryTransection modelGrowth restrictionSpinal cordTraumatic injury
2000
Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury
Kerr B, Cafferty W, Gupta Y, Bacon A, Wynick D, McMahon S, Thompson S. Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury. European Journal Of Neuroscience 2000, 12: 793-802. PMID: 10762308, DOI: 10.1046/j.1460-9568.2000.00967.x.Peer-Reviewed Original ResearchConceptsPeripheral nerve injuryNerve injuryBehavioral hypersensitivityExogenous galaninNociceptive processingAdult ratsNervous systemSpinal cord dorsal hornMutant miceNociceptive sensory inputsPersistent behavioral hypersensitivityNeuropathic pain behaviorsNeurotransmitter/neuromodulatorGalanin knockout miceCentral nervous systemC-fos expressionEndogenous galaninGalanin levelsNociceptive deficitsWild-type controlsDorsal hornChronic administrationGalanin expressionExcitatory effectsIntrathecal delivery