2021
Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8+ T-Cell Infiltration After Heart Transplantation
Bracamonte-Baran W, Gilotra N, Won T, Rodriguez K, Talor M, Oh B, Griffin J, Wittstein I, Sharma K, Skinner J, Johns R, Russell S, Anders R, Zhu Q, Halushka M, Brandacher G, Čiháková D. Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8+ T-Cell Infiltration After Heart Transplantation. Circulation Heart Failure 2021, 14: e007982. PMID: 34555935, PMCID: PMC8550427, DOI: 10.1161/circheartfailure.120.007982.Peer-Reviewed Original ResearchConceptsPD-L1 expressionT cell infiltrationPD-L1Heart transplantationEndothelial cellsHemodynamic parametersPD1/PD-L1 axisCD8 T-cell ratioMultivariate logistic regression analysisPeripheral blood mononuclear cellsMurine model resultsGraft endothelial cellsHeart transplant patientsPD-L1 axisT cell frequenciesT cell ratioHeart transplantation modelSurveillance endomyocardial biopsiesBlood mononuclear cellsHuman heart transplantationLogistic regression analysisGraft expressionLeukocyte compartmentLeukocyte patternModulates CD8
2020
Complete recovery of fulminant cytotoxic CD8 T‐cell‐mediated myocarditis after ECMELLA unloading and immunosuppression
Jurcova I, Rocek J, Bracamonte‐Baran W, Zelizko M, Netuka I, Maluskova J, Kautzner J, Cihakova D, Melenovsky V, Maly J. Complete recovery of fulminant cytotoxic CD8 T‐cell‐mediated myocarditis after ECMELLA unloading and immunosuppression. ESC Heart Failure 2020, 7: 1976-1981. PMID: 32485066, PMCID: PMC7373888, DOI: 10.1002/ehf2.12697.Peer-Reviewed Original ResearchConceptsMechanical circulatory supportCirculatory supportT cell-mediated myocarditisTemporary mechanical circulatory supportThird-degree atrioventricular blockWeeks of supportSevere biventricular failureT-cell predominanceExtracorporeal membrane oxygenationPrevious cardiac historyBiventricular failureCardiogenic shockVentricular dysfunctionLymphocytic myocarditisCardiac historyEndomyocardial biopsyMembrane oxygenationAtrioventricular blockVentricular unloadingMacrophage expansionMyocarditisFlow cytometryComplete recoverySustained recoveryImmunosuppressionCharacteristics and Outcomes of Pulmonary Angioplasty With or Without Stenting for Sarcoidosis-Associated Pulmonary Hypertension: Systematic Review and Individual Participant Data Meta-Analysis
daSilva-deAbreu A, Bracamonte-Baran W, Condado J, Babaliaros V, Tafur-Soto J, Mandras S. Characteristics and Outcomes of Pulmonary Angioplasty With or Without Stenting for Sarcoidosis-Associated Pulmonary Hypertension: Systematic Review and Individual Participant Data Meta-Analysis. Current Problems In Cardiology 2020, 46: 100616. PMID: 32532452, DOI: 10.1016/j.cpcardiol.2020.100616.Peer-Reviewed Original ResearchConceptsSarcoidosis-associated pulmonary hypertensionIndividual participant dataPulmonary angioplastyPulmonary hypertensionCase reportIndividual Participant Data Meta-AnalysisMulticenter registry studyNYHA FC IIIPulmonary vascular stenosisControlled Clinical TrialsSmall case seriesData Meta-AnalysisRegistry studyCase seriesFC IIIFocal stenosisDefinitive diagnosisClinical trialsPulmonary vesselsOutcome dataVascular stenosisStage IIIPatientsAngioplastySignificant improvementInnate Lymphoid Cells Play a Pathogenic Role in Pericarditis
Choi H, Won T, Hou X, Chen G, Bracamonte-Baran W, Talor M, Jurčová I, Szárszoi O, Čurnova L, Stříž I, Hooper J, Melenovský V, Čiháková D. Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis. Cell Reports 2020, 30: 2989-3003.e6. PMID: 32130902, PMCID: PMC7332109, DOI: 10.1016/j.celrep.2020.02.040.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementChemokine CCL11Disease SusceptibilityEosinophilsFemaleFibroblastsGene Expression RegulationHeartHeart Function TestsHumansImmunity, InnateInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Interleukin-5LymphocytesMaleMediastinumMice, Inbred BALB CPericarditisSignal TransductionUp-RegulationConceptsInnate lymphoid cellsEosinophilic pericarditisPathogenic roleMediastinal cavityLymphoid cellsGroup 2 innate lymphoid cellsCardiac fibroblastsDevelopment of pericarditisCardiac inflammationEotaxin-1Healthy controlsPericardial fluidCardiac diseasePericarditisB cellsSerous cavitiesILC2sEosinophilsPatientsMiceHeartCellsCritical roleFibroblastsInflammation
2019
Decreasing Rates of Acute Kidney Injury After Percutaneous Coronary Interventions Through Education and Standardized Order Sets in a Large Tertiary Teaching Center
daSilva-deAbreu A, Gurung S, Bracamonte-Baran W, Byrnes P, Balan P, Finkel K, Smalling R, Anderson H, Arain S. Decreasing Rates of Acute Kidney Injury After Percutaneous Coronary Interventions Through Education and Standardized Order Sets in a Large Tertiary Teaching Center. Current Problems In Cardiology 2019, 46: 100453. PMID: 31526518, DOI: 10.1016/j.cpcardiol.2019.100453.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPercutaneous coronary interventionAKI ratesKidney injuryCoronary interventionCardiac angiographyPost-PCI acute kidney injuryNational Cardiovascular Data RegistryTertiary teaching centerCare of patientsStandardized order setsStandardized electronic medical recordElectronic medical recordsCommon complicationTertiary centerMedical recordsCare teamData registryHealthcare costsMultilevel interventionsOrder setsTeaching centerPatientsAngiographyInterventionThe Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
Hou X, Chen G, Bracamonte-Baran W, Choi H, Diny N, Sung J, Hughes D, Won T, Wood M, Talor M, Hackam D, Klingel K, Davogustto G, Taegtmeyer H, Coppens I, Barin J, Čiháková D. The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis. Cell Reports 2019, 28: 172-189.e7. PMID: 31269438, PMCID: PMC6813836, DOI: 10.1016/j.celrep.2019.06.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, LyC-Mer Tyrosine KinaseCell DifferentiationCell ProliferationDisease Models, AnimalFibroblastsHumansInflammationInterleukin-17MacrophagesMiceMice, Inbred BALB CMice, KnockoutMicroscopy, Electron, TransmissionMonocytesMyocarditisMyocardiumParabiosisSignal TransductionTranscriptomeConceptsExperimental autoimmune myocarditisMonocyte-derived macrophagesIL-17AHeart failureCardiac fibroblastsMurine experimental autoimmune myocarditisIL-17A levelsMacrophage differentiationAutoimmune myocarditisAcute phaseCardiac fibrosisClinical correlationReceptor expressionLy6CMonocyte fateTypes of monocytesMacrophagesMyocarditisMHCIIMonocytesFibroblastsSupDifferentiationFibrosisSequalaeNon-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population
Bracamonte-Baran W, Chen G, Hou X, Talor M, Choi H, Davogustto G, Taegtmeyer H, Sung J, Hackam D, Nauen D, Čiháková D. Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population. Frontiers In Immunology 2019, 10: 634. PMID: 30984196, PMCID: PMC6450181, DOI: 10.3389/fimmu.2019.00634.Peer-Reviewed Original ResearchConceptsInnate lymphoid cellsIL-33 productionProgenitor-like featuresLymphoid cellsType 2IL-25 receptorNatural killer cellsSubsets of leukocytesAntigen-specific receptorsILC2 expansionInflammatory ILC2sAdoptive transferCardiac inflammationIL-33Killer cellsInflammatory conditionsMouse modelHealthy humansIschemic conditionsCardiac fibroblastsGATA3 expressionILC2Pathologic environmentHealthy heartIschemia
2018
Sca‐1+ cardiac fibroblasts promote development of heart failure
Chen G, Bracamonte‐Baran W, Diny N, Hou X, Talor M, Fu K, Liu Y, Davogustto G, Vasquez H, Taegtmeyer H, Frazier O, Waisman A, Conway S, Wan F, Čiháková D. Sca‐1+ cardiac fibroblasts promote development of heart failure. European Journal Of Immunology 2018, 48: 1522-1538. PMID: 29953616, PMCID: PMC6696927, DOI: 10.1002/eji.201847583.Peer-Reviewed Original ResearchConceptsHeart failureCardiac fibroblastsGM-CSFCardiac inflammationIL-17AFibroblast subsetsSca-1Post-infarct heart failureMyocardial infarction mouse modelExperimental autoimmune myocarditisHeart failure patientsCytokine production profileCardiac biopsy samplesAutoimmune myocarditisIschemic originFailure patientsIschemic cardiomyopathyInflammatory Ly6CImmune cellsMouse modelFl/Biopsy samplesMyocarditisMouse heartsSpecific ablation
2017
Cardiac Autoimmunity: Myocarditis
Bracamonte-Baran W, Čiháková D. Cardiac Autoimmunity: Myocarditis. Advances In Experimental Medicine And Biology 2017, 1003: 187-221. PMID: 28667560, PMCID: PMC5706653, DOI: 10.1007/978-3-319-57613-8_10.Peer-Reviewed Original ResearchConceptsAutoimmune processAdaptive T cell responsesGiant cell myocarditisT cell responsesVariable clinical presentationMonocytes/macrophagesImmunopathogenic featuresAcute complicationsAutoimmune myocarditisSystolic dysfunctionAcute myocarditisCryptic antigensHemodynamic complicationsHeart failureTreg inductionClinical presentationElectrophysiologic disturbancesHumoral responseClinical correlatesDifferent etiologiesInflammatory processImmune responseMyocarditisSpecific cytokinesChronic damageDonor-derived exosomes
Morelli A, Bracamonte-Baran W, Burlingham W. Donor-derived exosomes. Current Opinion In Organ Transplantation 2017, 22: 46-54. PMID: 27898464, PMCID: PMC5407007, DOI: 10.1097/mot.0000000000000372.Peer-Reviewed Original ResearchConceptsDonor MHC moleculesAntigen-presenting cellsSemidirect pathwayLymphoid organsMHC moleculesT cellsPassenger leukocytesDendritic cellsRecipient antigen-presenting cellsDonor antigen-presenting cellsAcute rejection responseDraining lymphoid organsHost dendritic cellsT cell allosensitizationT cell effectorsT helper cellsT cell helpAlloreactive T helper cellsExtracellular vesiclesAcute rejectionAlloantigen exposureDonor exosomesHeart transplantationMaternal microchimerismMaternal antigens
2015
Non-inherited maternal antigens, pregnancy, and allotolerance
Bracamonte-Baran W, Burlingham W. Non-inherited maternal antigens, pregnancy, and allotolerance. Biomedical Journal 2015, 38: 39-51. PMID: 25355389, DOI: 10.4103/2319-4170.143498.Peer-Reviewed Original ResearchConceptsNon-inherited maternal antigensNIMA effectMaternal antigensImmune systemFetal immune systemSemi-direct pathwayMaternal immune systemNormal human pregnancyBidirectional regulationGrowth factor βNIMA exposureRegulatory lymphocytesIL-35Paternal antigensHuman pregnancyImmunological phenomenaAntigenAllotoleranceFactor βMicrochimerismPregnancyIndirect pathwaysPolymorphic genesDirect pathwayPathway