2019
The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
Hou X, Chen G, Bracamonte-Baran W, Choi H, Diny N, Sung J, Hughes D, Won T, Wood M, Talor M, Hackam D, Klingel K, Davogustto G, Taegtmeyer H, Coppens I, Barin J, Čiháková D. The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis. Cell Reports 2019, 28: 172-189.e7. PMID: 31269438, PMCID: PMC6813836, DOI: 10.1016/j.celrep.2019.06.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, LyC-Mer Tyrosine KinaseCell DifferentiationCell ProliferationDisease Models, AnimalFibroblastsHumansInflammationInterleukin-17MacrophagesMiceMice, Inbred BALB CMice, KnockoutMicroscopy, Electron, TransmissionMonocytesMyocarditisMyocardiumParabiosisSignal TransductionTranscriptomeConceptsExperimental autoimmune myocarditisMonocyte-derived macrophagesIL-17AHeart failureCardiac fibroblastsMurine experimental autoimmune myocarditisIL-17A levelsMacrophage differentiationAutoimmune myocarditisAcute phaseCardiac fibrosisClinical correlationReceptor expressionLy6CMonocyte fateTypes of monocytesMacrophagesMyocarditisMHCIIMonocytesFibroblastsSupDifferentiationFibrosisSequalae
2017
Cardiac Autoimmunity: Myocarditis
Bracamonte-Baran W, Čiháková D. Cardiac Autoimmunity: Myocarditis. Advances In Experimental Medicine And Biology 2017, 1003: 187-221. PMID: 28667560, PMCID: PMC5706653, DOI: 10.1007/978-3-319-57613-8_10.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesAutoimmunityDisease Models, AnimalHumansImmunosuppressive AgentsMyocarditisMyocardiumPrognosisRisk FactorsSignal TransductionConceptsAutoimmune processAdaptive T cell responsesGiant cell myocarditisT cell responsesVariable clinical presentationMonocytes/macrophagesImmunopathogenic featuresAcute complicationsAutoimmune myocarditisSystolic dysfunctionAcute myocarditisCryptic antigensHemodynamic complicationsHeart failureTreg inductionClinical presentationElectrophysiologic disturbancesHumoral responseClinical correlatesDifferent etiologiesInflammatory processImmune responseMyocarditisSpecific cytokinesChronic damage