Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population
Bracamonte-Baran W, Chen G, Hou X, Talor M, Choi H, Davogustto G, Taegtmeyer H, Sung J, Hackam D, Nauen D, Čiháková D. Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population. Frontiers In Immunology 2019, 10: 634. PMID: 30984196, PMCID: PMC6450181, DOI: 10.3389/fimmu.2019.00634.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleFibroblastsGATA3 Transcription FactorGene Expression RegulationHumansImmunity, InnateInterleukin-33Killer Cells, NaturalMaleMiceMice, KnockoutMyocardial IschemiaMyocarditisMyocardiumPromyelocytic Leukemia Zinc Finger ProteinConceptsInnate lymphoid cellsIL-33 productionProgenitor-like featuresLymphoid cellsType 2IL-25 receptorNatural killer cellsSubsets of leukocytesAntigen-specific receptorsILC2 expansionInflammatory ILC2sAdoptive transferCardiac inflammationIL-33Killer cellsInflammatory conditionsMouse modelHealthy humansIschemic conditionsCardiac fibroblastsGATA3 expressionILC2Pathologic environmentHealthy heartIschemia