Complete recovery of fulminant cytotoxic CD8 T‐cell‐mediated myocarditis after ECMELLA unloading and immunosuppression
Jurcova I, Rocek J, Bracamonte‐Baran W, Zelizko M, Netuka I, Maluskova J, Kautzner J, Cihakova D, Melenovsky V, Maly J. Complete recovery of fulminant cytotoxic CD8 T‐cell‐mediated myocarditis after ECMELLA unloading and immunosuppression. ESC Heart Failure 2020, 7: 1976-1981. PMID: 32485066, PMCID: PMC7373888, DOI: 10.1002/ehf2.12697.Peer-Reviewed Original ResearchConceptsMechanical circulatory supportCirculatory supportT cell-mediated myocarditisTemporary mechanical circulatory supportThird-degree atrioventricular blockWeeks of supportSevere biventricular failureT-cell predominanceExtracorporeal membrane oxygenationPrevious cardiac historyBiventricular failureCardiogenic shockVentricular dysfunctionLymphocytic myocarditisCardiac historyEndomyocardial biopsyMembrane oxygenationAtrioventricular blockVentricular unloadingMacrophage expansionMyocarditisFlow cytometryComplete recoverySustained recoveryImmunosuppression