2021
Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8+ T-Cell Infiltration After Heart Transplantation
Bracamonte-Baran W, Gilotra N, Won T, Rodriguez K, Talor M, Oh B, Griffin J, Wittstein I, Sharma K, Skinner J, Johns R, Russell S, Anders R, Zhu Q, Halushka M, Brandacher G, Čiháková D. Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8+ T-Cell Infiltration After Heart Transplantation. Circulation Heart Failure 2021, 14: e007982. PMID: 34555935, PMCID: PMC8550427, DOI: 10.1161/circheartfailure.120.007982.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsB7-H1 AntigenCD8-Positive T-LymphocytesEndothelial CellsHeart FailureHeart TransplantationHumansLeukocytes, MononuclearMiceMiddle AgedProgrammed Cell Death 1 ReceptorConceptsPD-L1 expressionT cell infiltrationPD-L1Heart transplantationEndothelial cellsHemodynamic parametersPD1/PD-L1 axisCD8 T-cell ratioMultivariate logistic regression analysisPeripheral blood mononuclear cellsMurine model resultsGraft endothelial cellsHeart transplant patientsPD-L1 axisT cell frequenciesT cell ratioHeart transplantation modelSurveillance endomyocardial biopsiesBlood mononuclear cellsHuman heart transplantationLogistic regression analysisGraft expressionLeukocyte compartmentLeukocyte patternModulates CD8
2020
Complete recovery of fulminant cytotoxic CD8 T‐cell‐mediated myocarditis after ECMELLA unloading and immunosuppression
Jurcova I, Rocek J, Bracamonte‐Baran W, Zelizko M, Netuka I, Maluskova J, Kautzner J, Cihakova D, Melenovsky V, Maly J. Complete recovery of fulminant cytotoxic CD8 T‐cell‐mediated myocarditis after ECMELLA unloading and immunosuppression. ESC Heart Failure 2020, 7: 1976-1981. PMID: 32485066, PMCID: PMC7373888, DOI: 10.1002/ehf2.12697.Peer-Reviewed Original ResearchMeSH KeywordsAdultCD8-Positive T-LymphocytesFemaleHeart-Assist DevicesHumansImmunosuppression TherapyMyocarditisTreatment OutcomeYoung AdultConceptsMechanical circulatory supportCirculatory supportT cell-mediated myocarditisTemporary mechanical circulatory supportThird-degree atrioventricular blockWeeks of supportSevere biventricular failureT-cell predominanceExtracorporeal membrane oxygenationPrevious cardiac historyBiventricular failureCardiogenic shockVentricular dysfunctionLymphocytic myocarditisCardiac historyEndomyocardial biopsyMembrane oxygenationAtrioventricular blockVentricular unloadingMacrophage expansionMyocarditisFlow cytometryComplete recoverySustained recoveryImmunosuppressionTreg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance
Sullivan J, Tomita Y, Jankowska-Gan E, Lema D, Arvedson M, Nair A, Bracamonte-Baran W, Zhou Y, Meyer K, Zhong W, Sawant D, Szymczak-Workman A, Zhang Q, Workman C, Hong S, Vignali D, Burlingham W. Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance. Cell Reports 2020, 30: 1039-1051.e5. PMID: 31995748, PMCID: PMC7042971, DOI: 10.1016/j.celrep.2019.12.081.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCoculture TechniquesExtracellular VesiclesFemaleForkhead Transcription FactorsGene Knockout TechniquesHeart TransplantationImmune ToleranceImmunosuppression TherapyInterleukin-12 Subunit p35InterleukinsMiceMice, Inbred C57BLMice, Inbred CBAMice, TransgenicMicroscopy, Electron, TransmissionMinor Histocompatibility AntigensReceptors, CytokineT-Lymphocytes, RegulatoryConceptsIL-35Treg cellsInfectious toleranceExtracellular vesiclesExpression of Ebi3T regulatory (Treg) cellsImmunosuppressive cytokinesInterleukin-35Peripheral toleranceRegulatory cellsEpstein-BarrBystander lymphocytesSecondary suppressionReporter miceB lymphocytesEBI3Protein 3Foxp3LymphocytesGene reporterNovel mechanismP35 proteinCellsEV productionTregs