2020
Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis
Choi H, Won T, Hou X, Chen G, Bracamonte-Baran W, Talor M, Jurčová I, Szárszoi O, Čurnova L, Stříž I, Hooper J, Melenovský V, Čiháková D. Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis. Cell Reports 2020, 30: 2989-3003.e6. PMID: 32130902, PMCID: PMC7332109, DOI: 10.1016/j.celrep.2020.02.040.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementChemokine CCL11Disease SusceptibilityEosinophilsFemaleFibroblastsGene Expression RegulationHeartHeart Function TestsHumansImmunity, InnateInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Interleukin-5LymphocytesMaleMediastinumMice, Inbred BALB CPericarditisSignal TransductionUp-RegulationConceptsInnate lymphoid cellsEosinophilic pericarditisPathogenic roleMediastinal cavityLymphoid cellsGroup 2 innate lymphoid cellsCardiac fibroblastsDevelopment of pericarditisCardiac inflammationEotaxin-1Healthy controlsPericardial fluidCardiac diseasePericarditisB cellsSerous cavitiesILC2sEosinophilsPatientsMiceHeartCellsCritical roleFibroblastsInflammation
2017
Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance
Bracamonte-Baran W, Florentin J, Zhou Y, Jankowska-Gan E, Haynes W, Zhong W, Brennan T, Dutta P, Claas F, van Rood J, Burlingham W. Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 1099-1104. PMID: 28096390, PMCID: PMC5293109, DOI: 10.1073/pnas.1618364114.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsB7-2 AntigenB7-H1 AntigenCD4-Positive T-LymphocytesChimerismDendritic CellsExtracellular VesiclesFemaleFetomaternal TransfusionH-2 AntigensHistocompatibility Antigen H-2DHistocompatibility Antigens Class IIImmune ToleranceIsoantigensMaleMaternal-Fetal ExchangeMiceMice, Inbred C57BLMice, TransgenicModels, ImmunologicalPregnancyT-Cell Antigen Receptor SpecificityConceptsHost dendritic cellsCD4 T cellsDendritic cellsPD-L1Maternal microchimerismT cellsMyeloid DCsPlasmacytoid DCsMHC alloantigensTransgenic CD4 T cellsMyeloid dendritic cellsPlasmacytoid dendritic cellsExtracellular vesiclesAdoptive transferAntitumor immunityMaternal antigensTransplant toleranceTumor immunityMurine modelSerum EVsPhysiologic linkMHC complexesMiceSerum fractionsMode of action