2017
Donor-derived exosomes
Morelli A, Bracamonte-Baran W, Burlingham W. Donor-derived exosomes. Current Opinion In Organ Transplantation 2017, 22: 46-54. PMID: 27898464, PMCID: PMC5407007, DOI: 10.1097/mot.0000000000000372.Peer-Reviewed Original ResearchConceptsDonor MHC moleculesAntigen-presenting cellsSemidirect pathwayLymphoid organsMHC moleculesT cellsPassenger leukocytesDendritic cellsRecipient antigen-presenting cellsDonor antigen-presenting cellsAcute rejection responseDraining lymphoid organsHost dendritic cellsT cell allosensitizationT cell effectorsT helper cellsT cell helpAlloreactive T helper cellsExtracellular vesiclesAcute rejectionAlloantigen exposureDonor exosomesHeart transplantationMaternal microchimerismMaternal antigens
2016
Kinetics of Alloantigen-Specific Regulatory CD4 T Cell Development and Tissue Distribution After Donor-Specific Transfusion and Costimulatory Blockade
Tomita Y, Satomi M, Bracamonte-Baran W, Jankowska Gan E, Workman A, Workman C, Vignali D, Burlingham W. Kinetics of Alloantigen-Specific Regulatory CD4 T Cell Development and Tissue Distribution After Donor-Specific Transfusion and Costimulatory Blockade. Transplantation Direct 2016, 2: e73. PMID: 27500263, PMCID: PMC4946513, DOI: 10.1097/txd.0000000000000580.Peer-Reviewed Original ResearchCD4 T cellsDonor-specific transfusionRegulatory T cellsTreg cell subsetsT cellsCell subsetsLymphoid tissueTissue-resident memory T cellsCD4 T cell developmentDouble reporter miceMemory T cellsSecondary lymphoid organsT cell developmentCD40L blockadeRecipient antigensTrans vivoCostimulatory blockadeCytokine IL10Graft outcomeTreg cellsTransplant toleranceAllospecific responsesLymphoid organsDonor organsReporter mice