Sca‐1+ cardiac fibroblasts promote development of heart failure
Chen G, Bracamonte‐Baran W, Diny N, Hou X, Talor M, Fu K, Liu Y, Davogustto G, Vasquez H, Taegtmeyer H, Frazier O, Waisman A, Conway S, Wan F, Čiháková D. Sca‐1+ cardiac fibroblasts promote development of heart failure. European Journal Of Immunology 2018, 48: 1522-1538. PMID: 29953616, PMCID: PMC6696927, DOI: 10.1002/eji.201847583.Peer-Reviewed Original ResearchConceptsHeart failureCardiac fibroblastsGM-CSFCardiac inflammationIL-17AFibroblast subsetsSca-1Post-infarct heart failureMyocardial infarction mouse modelExperimental autoimmune myocarditisHeart failure patientsCytokine production profileCardiac biopsy samplesAutoimmune myocarditisIschemic originFailure patientsIschemic cardiomyopathyInflammatory Ly6CImmune cellsMouse modelFl/Biopsy samplesMyocarditisMouse heartsSpecific ablation