2020
Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis
Choi H, Won T, Hou X, Chen G, Bracamonte-Baran W, Talor M, Jurčová I, Szárszoi O, Čurnova L, Stříž I, Hooper J, Melenovský V, Čiháková D. Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis. Cell Reports 2020, 30: 2989-3003.e6. PMID: 32130902, PMCID: PMC7332109, DOI: 10.1016/j.celrep.2020.02.040.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementChemokine CCL11Disease SusceptibilityEosinophilsFemaleFibroblastsGene Expression RegulationHeartHeart Function TestsHumansImmunity, InnateInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Interleukin-5LymphocytesMaleMediastinumMice, Inbred BALB CPericarditisSignal TransductionUp-RegulationConceptsInnate lymphoid cellsEosinophilic pericarditisPathogenic roleMediastinal cavityLymphoid cellsGroup 2 innate lymphoid cellsCardiac fibroblastsDevelopment of pericarditisCardiac inflammationEotaxin-1Healthy controlsPericardial fluidCardiac diseasePericarditisB cellsSerous cavitiesILC2sEosinophilsPatientsMiceHeartCellsCritical roleFibroblastsInflammation
2019
Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population
Bracamonte-Baran W, Chen G, Hou X, Talor M, Choi H, Davogustto G, Taegtmeyer H, Sung J, Hackam D, Nauen D, Čiháková D. Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population. Frontiers In Immunology 2019, 10: 634. PMID: 30984196, PMCID: PMC6450181, DOI: 10.3389/fimmu.2019.00634.Peer-Reviewed Original ResearchConceptsInnate lymphoid cellsIL-33 productionProgenitor-like featuresLymphoid cellsType 2IL-25 receptorNatural killer cellsSubsets of leukocytesAntigen-specific receptorsILC2 expansionInflammatory ILC2sAdoptive transferCardiac inflammationIL-33Killer cellsInflammatory conditionsMouse modelHealthy humansIschemic conditionsCardiac fibroblastsGATA3 expressionILC2Pathologic environmentHealthy heartIschemia