2020
Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance
Sullivan J, Tomita Y, Jankowska-Gan E, Lema D, Arvedson M, Nair A, Bracamonte-Baran W, Zhou Y, Meyer K, Zhong W, Sawant D, Szymczak-Workman A, Zhang Q, Workman C, Hong S, Vignali D, Burlingham W. Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance. Cell Reports 2020, 30: 1039-1051.e5. PMID: 31995748, PMCID: PMC7042971, DOI: 10.1016/j.celrep.2019.12.081.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCoculture TechniquesExtracellular VesiclesFemaleForkhead Transcription FactorsGene Knockout TechniquesHeart TransplantationImmune ToleranceImmunosuppression TherapyInterleukin-12 Subunit p35InterleukinsMiceMice, Inbred C57BLMice, Inbred CBAMice, TransgenicMicroscopy, Electron, TransmissionMinor Histocompatibility AntigensReceptors, CytokineT-Lymphocytes, RegulatoryConceptsIL-35Treg cellsInfectious toleranceExtracellular vesiclesExpression of Ebi3T regulatory (Treg) cellsImmunosuppressive cytokinesInterleukin-35Peripheral toleranceRegulatory cellsEpstein-BarrBystander lymphocytesSecondary suppressionReporter miceB lymphocytesEBI3Protein 3Foxp3LymphocytesGene reporterNovel mechanismP35 proteinCellsEV productionTregs
2017
Donor-derived exosomes
Morelli A, Bracamonte-Baran W, Burlingham W. Donor-derived exosomes. Current Opinion In Organ Transplantation 2017, 22: 46-54. PMID: 27898464, PMCID: PMC5407007, DOI: 10.1097/mot.0000000000000372.Peer-Reviewed Original ResearchConceptsDonor MHC moleculesAntigen-presenting cellsSemidirect pathwayLymphoid organsMHC moleculesT cellsPassenger leukocytesDendritic cellsRecipient antigen-presenting cellsDonor antigen-presenting cellsAcute rejection responseDraining lymphoid organsHost dendritic cellsT cell allosensitizationT cell effectorsT helper cellsT cell helpAlloreactive T helper cellsExtracellular vesiclesAcute rejectionAlloantigen exposureDonor exosomesHeart transplantationMaternal microchimerismMaternal antigensModification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance
Bracamonte-Baran W, Florentin J, Zhou Y, Jankowska-Gan E, Haynes W, Zhong W, Brennan T, Dutta P, Claas F, van Rood J, Burlingham W. Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 1099-1104. PMID: 28096390, PMCID: PMC5293109, DOI: 10.1073/pnas.1618364114.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsB7-2 AntigenB7-H1 AntigenCD4-Positive T-LymphocytesChimerismDendritic CellsExtracellular VesiclesFemaleFetomaternal TransfusionH-2 AntigensHistocompatibility Antigen H-2DHistocompatibility Antigens Class IIImmune ToleranceIsoantigensMaleMaternal-Fetal ExchangeMiceMice, Inbred C57BLMice, TransgenicModels, ImmunologicalPregnancyT-Cell Antigen Receptor SpecificityConceptsHost dendritic cellsCD4 T cellsDendritic cellsPD-L1Maternal microchimerismT cellsMyeloid DCsPlasmacytoid DCsMHC alloantigensTransgenic CD4 T cellsMyeloid dendritic cellsPlasmacytoid dendritic cellsExtracellular vesiclesAdoptive transferAntitumor immunityMaternal antigensTransplant toleranceTumor immunityMurine modelSerum EVsPhysiologic linkMHC complexesMiceSerum fractionsMode of action