2018
OP0224 Adamts-12 protects against inflammatory arthritis through interacting with proinflammatory ctgf
Fu W, Wei J, Hettinghouse A, He W, Liu C. OP0224 Adamts-12 protects against inflammatory arthritis through interacting with proinflammatory ctgf. Annals Of The Rheumatic Diseases 2018, 77: 160. DOI: 10.1136/annrheumdis-2018-eular.4748.Peer-Reviewed Original ResearchCollagen-induced arthritisClinical arthritis scoreInflammatory arthritisADAMTS-12Arthritis scoreCTGF antibodyIL-1βDisease onsetHistological analysisAccelerated disease onsetCIA mouse modelAnti-inflammatory cytokinesRheumatoid arthritis developmentPro-inflammatory roleFurther tissue destructionDestruction of boneSignificant increaseCritical regulatorCIA miceRA patientsArthritis developmentArthritis incidenceKO miceNormal inflammationSafranin O staining
2017
Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models
Wei J, Fu W, Ding Y, Hettinghouse A, Lendhey M, Schwarzkopf R, Kennedy O, Liu C. Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models. Arthritis Research & Therapy 2017, 19: 280. PMID: 29258611, PMCID: PMC5735869, DOI: 10.1186/s13075-017-1485-8.Peer-Reviewed Original ResearchConceptsTherapeutic effectOA modelPain-related markersAnti-catabolic effectsRole of progranulinDegenerative joint diseaseMurine OA modelMultiple murine modelsNew therapeutic alternativesTumor necrosis factor receptorIntra-articular deliveryNecrosis factor receptorInflammatory arthritisPGRN deficiencyOA phenotypeSafranin O stainingTherapeutic alternativeRat modelJoint diseaseOsteoarthritis progressionPreventative effectMurine modelCartilage degradationDegenerative factorsEarly osteoarthritis