Role of ADAMTS‐12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor
Wei J, Fu W, Hettinghouse A, He W, Lipson K, Liu C. Role of ADAMTS‐12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor. Arthritis & Rheumatology 2018, 70: 1745-1756. PMID: 29750395, PMCID: PMC6203634, DOI: 10.1002/art.40552.Peer-Reviewed Original ResearchConceptsConnective tissue growth factorCIA mouse modelADAMTS-12Inflammatory arthritisTissue growth factorMouse modelCollagen-induced arthritis modelGrowth factorRheumatoid arthritis developmentEnzyme-linked immunosorbentRA patientsArthritis developmentPannus formationSerum levelsCartilage destructionArthritis modelInflammatory cytokinesEnhanced osteoclastogenesisHealthy subjectsArthritisAnkle jointTomography scanningInflammationSusceptibility genesCritical regulatorOP0224 Adamts-12 protects against inflammatory arthritis through interacting with proinflammatory ctgf
Fu W, Wei J, Hettinghouse A, He W, Liu C. OP0224 Adamts-12 protects against inflammatory arthritis through interacting with proinflammatory ctgf. Annals Of The Rheumatic Diseases 2018, 77: 160. DOI: 10.1136/annrheumdis-2018-eular.4748.Peer-Reviewed Original ResearchCollagen-induced arthritisClinical arthritis scoreInflammatory arthritisADAMTS-12Arthritis scoreCTGF antibodyIL-1βDisease onsetHistological analysisAccelerated disease onsetCIA mouse modelAnti-inflammatory cytokinesRheumatoid arthritis developmentPro-inflammatory roleFurther tissue destructionDestruction of boneSignificant increaseCritical regulatorCIA miceRA patientsArthritis developmentArthritis incidenceKO miceNormal inflammationSafranin O staining