An integrated model of N6-methyladenosine regulators to predict tumor aggressiveness and immune evasion in pancreatic cancer
Zhou Z, Zhang J, Xu C, Yang J, Zhang Y, Liu M, Shi X, Li X, Zhan H, Chen W, McNally L, Fung K, Luo W, Houchen C, He Y, Zhang C, Li M. An integrated model of N6-methyladenosine regulators to predict tumor aggressiveness and immune evasion in pancreatic cancer. EBioMedicine 2021, 65: 103271. PMID: 33714027, PMCID: PMC7966986, DOI: 10.1016/j.ebiom.2021.103271.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsPancreatic ductal adenocarcinomaImmune evasionCheckpoint inhibitorsOverall survivalImmune infiltrationPancreatic cancerTumor aggressivenessM6A regulatorsSomatic copy number alterationsT cell exhaustionDismal overall survivalMutation profilesN6-methyladenosine regulatorsHigh response ratePancreatic cancer prognosisClassical pancreatic ductal adenocarcinomaCancer CenterColorectal cancerTumor recurrenceDuctal adenocarcinomaM6AscoreBreast cancerTreatment responseCell exhaustion