2018
Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons
Li D, Musante V, Zhou W, Picciotto MR, Nairn AC. Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons. Journal Of Biological Chemistry 2018, 293: 11179-11194. PMID: 29802198, PMCID: PMC6052221, DOI: 10.1074/jbc.ra117.001519.Peer-Reviewed Original ResearchConceptsSerine/threonine phosphatase PP2AStriatin-interacting phosphataseRNA knockdown approachB subunitSTRIPAK complexPhosphatase PP2AProtein phosphataseMultiprotein complexesKnockdown approachStriatin familyMutant constructsStriatal neuronal culturesPP2ANeuronal developmentPrimary striatal neuronal culturesDendritic phenotypeKnockdown modelSynapse formationSubunitsSpine developmentSelective roleReduced expressionNeuron maturationNeuronal culturesStriatal neurons
2014
Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex
Moore A, Zhou W, Sirois C, Belinsky G, Zecevic N, Antic S. Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: e3919-e3928. PMID: 25197082, PMCID: PMC4169969, DOI: 10.1073/pnas.1405253111.Peer-Reviewed Original ResearchConceptsHuman fetal cortexAction potential firingFetal cortexSP neuronsSpontaneous activitySpontaneous depolarizationsYoung postmitotic neuronsGlycinergic synaptic transmissionConnexin-based gap junctionsElectrical activityAcute cortical slicesSpontaneous electrical activityWhole-cell recordingsConnexin hemichannelsGap junctionsHuman subplate neuronsPresence of connexinsSubplate neuronsSecond trimesterCortical slicesSynaptic contactsSynaptic transmissionImmunohistochemical analysisSP zonePostmitotic neurons
2012
Rapid dopaminergic and GABAergic modulation of calcium and voltage transients in dendrites of prefrontal cortex pyramidal neurons
Zhou W, Antic S. Rapid dopaminergic and GABAergic modulation of calcium and voltage transients in dendrites of prefrontal cortex pyramidal neurons. The Journal Of Physiology 2012, 590: 3891-3911. PMID: 22641784, PMCID: PMC3476639, DOI: 10.1113/jphysiol.2011.227157.Peer-Reviewed Original ResearchConceptsDendritic calcium transientsAction potentialsDopamine effectsSame dendriteCalcium transientsPrefrontal cortex pyramidal neuronsT-type calcium channel blockersDendritic calcium influxCortex pyramidal neuronsCalcium channel blockersMidbrain dopaminergic neuronsCalcium-sensitive dyeAP backpropagationDopaminergic stimulationGABAergic modulationPyramidal neuronsDopaminergic neuronsPulses of GABAD1 antagonistDopamine applicationDopaminergic suppressionDopaminergic inputSomatic excitabilityD1 agonistChannel blockers
2011
Spontaneous Electrical Activity in the Human Fetal Cortex In Vitro
Moore A, Zhou W, Jakovcevski I, Zecevic N, Antic S. Spontaneous Electrical Activity in the Human Fetal Cortex In Vitro. Journal Of Neuroscience 2011, 31: 2391-2398. PMID: 21325506, PMCID: PMC3564513, DOI: 10.1523/jneurosci.3886-10.2011.Peer-Reviewed Original ResearchConceptsAction potential firingSpontaneous electrical activitySP neuronsPlateau depolarizationsHuman fetal neuronsElectrical activityHuman fetal cortexFunctional synaptic contactsHuman cerebral cortexSpontaneous network activitySlow-wave sleepHuman postmortem tissueSlow oscillatory patternsGABA ionotropic receptorsHuman subplate neuronsFetal neuronsSubplate neuronsCerebral cortexGestational weeksSynaptic contactsFetal cortexPostsynaptic potentialsCortical neuronsAdult neocortexSynaptic inputs
2007
Intracellular long-wavelength voltage-sensitive dyes for studying the dynamics of action potentials in axons and thin dendrites
Zhou W, Yan P, Wuskell J, Loew L, Antic S. Intracellular long-wavelength voltage-sensitive dyes for studying the dynamics of action potentials in axons and thin dendrites. Journal Of Neuroscience Methods 2007, 164: 225-239. PMID: 17560661, PMCID: PMC2001318, DOI: 10.1016/j.jneumeth.2007.05.002.Peer-Reviewed Original Research