(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo
Zhou R, Zhang F, He P, Zhou W, Wu Q, Xu J, Zhou Y, Tang W, Li X, Yang Y, Li Y, Zuo J. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo. International Immunopharmacology 2005, 5: 1895-1903. PMID: 16275624, DOI: 10.1016/j.intimp.2005.06.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell ProliferationCell SurvivalCells, CulturedCytokinesDinitrofluorobenzeneDisease Models, AnimalDiterpenesDrugs, Chinese HerbalFemaleHypersensitivity, DelayedImmunosuppressive AgentsLymphocyte ActivationLymphocyte Culture Test, MixedMaleMiceMice, Inbred BALB CSheepSpleenT-LymphocytesConceptsLLDT-8Immunosuppressive activityBLAB/c miceType hypersensitivity reactionSheep red blood cellsTh1-type cytokinesHumoral immune responseProliferation of splenocytesImmune-related diseasesHigh immunosuppressive activityPotential therapeutic agentNovel triptolide analogRed blood cellsLymphocyte reactionHypersensitivity reactionsImmunosuppressive effectsInflammatory cytokinesLow acute toxicityC miceImmune responseType cytokinesTriptolide analoguesAntibody productionTherapeutic agentsBlood cells