A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo
Zhou W, Wu J, Wu Q, Wang J, Zhou Y, Zhou R, He P, Li X, Yang Y, Zhang Y, Li Y, Zuo J. A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo. Acta Pharmacologica Sinica 2005, 26: 1352-1358. PMID: 16225758, DOI: 10.1111/j.1745-7254.2005.00232.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory Agents, Non-SteroidalArtemisininsCell ProliferationCells, CulturedCytokinesDose-Response Relationship, DrugHemolysisHypersensitivity, DelayedImmunosuppressive AgentsInhibitory Concentration 50Interferon-gammaInterleukin-12Lymphocyte Culture Test, MixedMaleMiceMice, Inbred BALB CMice, Inbred C57BLSuccinatesConceptsDelayed-type hypersensitivityMixed lymphocyte reactionProliferation of splenocytesSheep red blood cellsImmunosuppressive agentsCytokine productionT-cell-mediated delayed-type hypersensitivityImmunosuppressive activityVivo immune activityProinflammatory cytokine productionIL-2 secretionNovel artemisinin derivativesEnzyme-linked immunosorbentDose-dependent mannerStrong immunosuppressive activityPotential immunosuppressive agentsRed blood cellsLymphocyte reactionImmunosuppressive effectsQuantitative hemolysisImmune activityMouse modelArtemisinin derivativesConA stimulationBlood cells(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo
Zhou R, Zhang F, He P, Zhou W, Wu Q, Xu J, Zhou Y, Tang W, Li X, Yang Y, Li Y, Zuo J. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo. International Immunopharmacology 2005, 5: 1895-1903. PMID: 16275624, DOI: 10.1016/j.intimp.2005.06.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell ProliferationCell SurvivalCells, CulturedCytokinesDinitrofluorobenzeneDisease Models, AnimalDiterpenesDrugs, Chinese HerbalFemaleHypersensitivity, DelayedImmunosuppressive AgentsLymphocyte ActivationLymphocyte Culture Test, MixedMaleMiceMice, Inbred BALB CSheepSpleenT-LymphocytesConceptsLLDT-8Immunosuppressive activityBLAB/c miceType hypersensitivity reactionSheep red blood cellsTh1-type cytokinesHumoral immune responseProliferation of splenocytesImmune-related diseasesHigh immunosuppressive activityPotential therapeutic agentNovel triptolide analogRed blood cellsLymphocyte reactionHypersensitivity reactionsImmunosuppressive effectsInflammatory cytokinesLow acute toxicityC miceImmune responseType cytokinesTriptolide analoguesAntibody productionTherapeutic agentsBlood cells