Inhibition of S-Adenosyl-l-homocysteine Hydrolase Induces Immunosuppression
Wu Q, Fu Y, Zhou W, Wang J, Feng Y, Liu J, Xu J, He P, Zhou R, Tang W, Wang G, Zhou Y, Yang Y, Ding J, Li X, Chen X, Yuan C, Lawson B, Zuo J. Inhibition of S-Adenosyl-l-homocysteine Hydrolase Induces Immunosuppression. Journal Of Pharmacology And Experimental Therapeutics 2005, 313: 705-711. PMID: 15640397, DOI: 10.1124/jpet.104.080416.Peer-Reviewed Original ResearchMeSH KeywordsAdenosylhomocysteinaseAnimalsAntigens, CDB7-1 AntigenB7-2 AntigenCell SurvivalDose-Response Relationship, DrugDown-RegulationEnzyme ActivationEnzyme InhibitorsFemaleGrowth InhibitorsImmunosuppressive AgentsLymphocyte Culture Test, MixedMaleMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLConceptsTHP-1 cellsImmunosuppressive effectsTumor necrosis factor-alpha productionDelayed-type hypersensitivity reactionS-adenosyl-L-homocysteine hydrolaseNecrosis factor-alpha productionLevels of CD80IL-12 productionMixed lymphocyte reactionT cell inhibitionHuman monocytic THP-1 cellsThioglycollate-stimulated peritoneal macrophagesT cell functionT cell proliferationImmunosuppressive therapeutic agentsT cell costimulationMonocytic THP-1 cellsDose-dependent mannerImmunologic effectsIL-12Lymphocyte reactionHypersensitivity reactionsCytokine outputMacrophage activationType III inhibitor